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• Clinical Article •
Altered gray matter volume in primary trigeminal neuralgia: a voxel based morphometry MRI study
GUO Lin-ying  ZHU Wen-zhen  TIAN Tian  YANG Shi-qi  QIN Yuan-yuan  TANG Xiang-yu  WANG Jian  ZHANG Ju 

DOI:10.3969/j.issn.1674-8034.2015.12.002.


[Abstract] Objective: To detect whether there is gray matter volume (GMV) alteration and further analyze the involvement of central nervous system in pain processing in trigeminal neuralgia patients.Materials and Methods: Nineteen patients diagnosed with trigeminal neuralgia and twenty-two age-matched, sex-matched normal volunteers as controls were recruited. T1-weighted 3D BRAVO sagittal images were obtained from all subjects. Voxel based morphometry(VBM) was used to identify GMV differences between patients and normal controls. The correlation between altered GMVs and disease duration as well as altered GMVs and pain intensity were also analyzed in trigeminal neuralgia patients.Results: Compared with normal controls, patients with trigeminal neuralgia had decreased GMV in left anterior cingulate as well as increased GMVs in right superior frontal gyrus, right insula, right putamen and bilateral cerebellum. Otherwise, we found a negative correlation between pain duration and altered GMV of the left anterior cingulate which is an important region for the development and maintenance of pain in trigeminal neuralgia.Conclusion: The altered GMV in central nervous system and the negative correlation between disease duration and altered GMV of the anterior cingulate may suggest that these central brain regions are extremely important for the development and maintenance of pain in trigeminal neuralgia, which reveals that exploring the central mechanisms of pain processing in trigeminal neuralgia may benefit new therapeutic methods in the future.
[Keywords] Trigeminal neuralgia；Central nervous system；Magnetic resonance imaging；Voxel based morphometry

GUO Lin-ying Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

ZHU Wen-zhen* Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

TIAN Tian Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

YANG Shi-qi Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

QIN Yuan-yuan Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

TANG Xiang-yu Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

WANG Jian Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

ZHANG Ju Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Zhu WZ, E-mail: zhuwenzhen@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Program of the Ministry of Science and Technology of China during the "12th Five-Year Plan" No. 2011BAI08B10 National Natural Science Foundation of China No. 81171308, 81401389
Received  2015-10-08
Accepted  2015-11-09
DOI: 10.3969/j.issn.1674-8034.2015.12.002
DOI:10.3969/j.issn.1674-8034.2015.12.002.

[1]
金军，汤小俐，香辉,等. 3.0 T MRI 3D-TOF序列联合3D-FIESTA序列结合多平面重建在三叉神经微血管减压术术前评估中的应用价值.磁共振成像, 2015, 6(4): 277-282.
[2]
刘彩霞，鲍海华，李伟霞,等.慢性高原病患者脑灰质变化的VBM-MRI研究.磁共振成像, 2014, 5(3): 211-215.
[3]
Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron, 2007, 55(3): 377-391.
[4]
Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain, 1975, 1(3): 277-299.
[5]
谢文强，李伟彦.神经病理性疼痛的脑功能成像研究进展.医学综述, 2012, 18(8): 1232-1235.
[6]
Wiech K, Ploner M, Tracey I. Neurocognitive aspects of pain perception. Trends Cogn Sci, 2008, 12(8): 306-313.
[7]
May A. A review of diagnostic and functional imaging in headache. J Headache Pain, 2006, 7(4): 174-184.
[8]
Lev R, Granovsky Y, Yarnitsky D. Orbitofrontal disinhibition of pain in migraine with aura: an interictal EEG-mapping study. Cephalalgia, 2010, 30(8): 910-918.
[9]
Bingel U, Tracey I. Imaging CNS modulation of pain in humans. Physiology (Bethesda), 2008, 23(6): 371-380.
[10]
Desouza DD, Moayedi M, Chen DQ, et al. Sensorimotor and pain modulation brain abnormalities in trigeminal neuralgia: a paroxysmal, sensory-triggered neuropathic pain. PLoS One, 2013, 8(6): e66340.
[11]
Obermann M, Rodriguez-Raecke R, Naegel S, et al. Gray matter volume reduction reflects chronic pain in trigeminal neuralgia. Neuroimage, 2013, 74(10): 352-358.
[12]
Vania AA, Catherine BM, Rolf-Detlef T, et al. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain, 2005, 9(4): 463-484.
[13]
Brown CA, Seymour B, El-Deredy W, et al. Confidence in beliefs about pain predicts expectancy effects on pain perception and anticipatory processing in right anterior insula. Pain, 2008, 139(2): 324-332.
[14]
Wiech K, Tracey I. The influence of negative emotions on pain: behavioral effects and neural mechanisms. Neuroimage, 2009, 47(3): 987-994.
[15]
Davis KD, Moayedi M. Central mechanisms of pain revealed through functional and structural MRI. J Neuroimmune Pharmacol, 2013, 8(3): 518-534.
[16]
Bingel U, Schoell E, Herken W, et al. Habituation to painful stimulation involves the antinociceptive system. Pain, 2007, 131(1-2): 21-30.
[17]
Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science, 2000, 288(5472): 1765-1769.
[18]
Seifert F, Maihofner C. Functional and structural imaging of pain-induced neuroplasticity. Curr Opin Anaesthesiol, 2011, 24(5): 515-523.
[19]
Rodriguez-Raecke R, Niemeier A, Ihle K, et al. Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci, 2009, 29(44): 13746-13750.

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