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• Clinical Article •
Quantitative evaluation of hemodynamics changes in childhood moyamoya disease after revascularization surgery using perfusion-weighted MR imaging
WANG Yi-tuo  HAN Cong  ZUO Zhi-wei  XING Xu-dong  QIAO Peng-gang  LI Gong-jie 

DOI:10.3969/j.issn.1674-8034.2015.12.004.


[Abstract] Objective: To evaluate whether Perfusion-Weighted Imaging (PWI) can depict hemodynamic status and its relationship with Digital Subtraction Angiography (DSA) and whether changes in PWI imaging after revascularization surgery are correlated with clinical outcomes in childhood moyamoya disease.Materials and Methods: Pre- and postoperative PWI imaging data in 16 children with moyamoya disease (mean age, 9.88 years; range, 5-15 years) were included, which involved regional Time To Peak (rTTP), regional Cerebral Blood Volume (rCBV), regional Cerebral Blood Flow (rCBF) and regional Mean Transit Time (rMTT). Suzuki stages on each side of the brain hemisphere were evaluated by the DSA results. Pre- and postoperative PWI parameters were compared by using a paired t test; relationships between PWI parameters and clinical outcomes were investigated by using independent-samples t test; relationships between PWI parameters and Sukuzi Stages were investigated by using Spearman correlation analysis, with a significance level of 0.05.Results: At early stage of MMD, Suzuki stages were correlated with blood perfusion change. However, no correlation was demonstrated when suzuki stages>II. rTTP decreased significantly after revascularization surgery. Change in rTTP was significantly different in the clinical outcome groups.Conclusion: MR-PWI can quantitatively depict hemodynamic status and evaluate hemodynamic changes after revascularization surgery in moyamoya disease.
[Keywords] Moyamoya disease；Children；Perfusion weighted imaging；Angiography, Digital subtraction；Revascularization surgery；Hemodynamics；Brain ischemia

WANG Yi-tuo Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

HAN Cong Department of Neurosurgery, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

ZUO Zhi-wei Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

XING Xu-dong Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

QIAO Peng-gang* Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

LI Gong-jie* Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China

*Correspondence to: Qiao PG, E-mail: qiaopenggang@sina.com; Li GJ, E-mail: ligj307@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of youth project Beijing municipal natural science foundation No. 7144231 Capital characteristic clinic project No. Z141107002514171
Received  2015-09-14
Accepted  2015-10-20
DOI: 10.3969/j.issn.1674-8034.2015.12.004
DOI:10.3969/j.issn.1674-8034.2015.12.004.

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