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• Clinical Article •
The relevant risk factors for analyzing the occurrence and distribution of cerebral microbleedsin old patients with transient ischemic attack
LIAO Yun-jie  LIU Yin  LI Wan-meng  CHEN Bei  WANG Wei 

DOI:10.3969/j.issn.1674-8034.2015.12.006.


[Abstract] Objective: To investigate the relevant risk factors for analyzing the occurrence and distribution of cerebral microbleeds(CMB) in old patients with transient ischemic attack(TIA).Materials and Methods: One hundred and eighty-two old patients with TIA diagnosed by physician were collected from September 2013 to July 2015 in our hospital, whose clinical data and MRI data were analyzed by two neurologists and two radiologists respectively. Clinical data included age, gender, clinical symptoms, diagnosis, confounding diseases, IADL score and biochemical test results(such as triglyceride(TG)and high-density lipoprotein(HDL)). MRI data contained the location and distribution of CMB, the degree of lacunar infarction(LI), periventricularhighsignal(PVH) and deep white matter hyperintensities(DWMH). Then the relative risk factors were analysis for the occurrence and distribution of CMB in old patients with TIA.Results: In comparison with CMB(-)group, there were higher age, LI amount, PVH and DWMH grading and lower HDL in CMB(+) group, which had statistical significance(P<0.05), but IADL score was not statistical significance(P>0.05) in both groups. For the distribution of CMB, there were higher LI and DWMH in diffuse type than cerebral lobe and deep structure type, which had statistical significance(P<0.05). but HDL level was not statistical significance(P>0.05) among three type groups. The relative risk factors were serious PVH and high TG for cerebral lobe type(OR=7.01)and deep structure type(OR=6.80)respectively, and were serious DWMH and LI amount for diffuse type(OR=9.4; OR= 7.88).Conclusion: The occurrence and distribution of CMB in old patients with TIA are related to age, LI amount, TG, PVH and DWMH grading, which are helpful to the diagnosis and treatment for CMB patients.
[Keywords] Cerebral hemorrhage；Transient ischemic attack；Susceptiblity weighted imaging；White matter hyperintensity；Magnetic resonance imaging

LIAO Yun-jie Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

LIU Yin Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

LI Wan-meng Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

CHEN Bei Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

WANG Wei* Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China

*Correspondence to: Wang W, E-mail: cjr.wangwei@vip.163.com

Conflicts of interest   None.

Received  2015-08-24
DOI: 10.3969/j.issn.1674-8034.2015.12.006
DOI:10.3969/j.issn.1674-8034.2015.12.006.

[1]
柴超，夏爽，沈文.脑微出血的空间与时间分布及对临床治疗的影响.国际医学放射学杂志, 2013, 36(4): 324-327.
[2]
Greenberg SM, Vernooij MW, Cordonnier C, et al．Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol, 2009, 8(2): 165-174．
[3]
Charidimou A, Jager HR, Werring DJ, et al. Cerebral microbleed detection and mapping: principles, methodological aspects and rationale in vascular dementia．Exp Gerontol, 2012, 47(11):843-852．
[4]
Werring DJ. Cerebral microbleeds: clinical and pathophysiological significance. J Neuroimaging, 2007, 17(3): 193-203.
[5]
Offenbacher H, Fazekas F, Schmidt R, et a1. MR of cerebral abnormalitiesconcomitant withprimary intracerebral hematomas. AJNR Am J Neuroradiol, 1996, 17(3): 573-578.
[6]
高中宝，赵杏丽，王炜,等.老年脑微出血分布特点及相关危险因素分析.解放军医学院学报, 2013, 34(3): 201-207.
[7]
Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of loci of signalloss on gradient-echo T2-weighted MR images in patients with spontaneousintracerebral hemorrhage: evidence of microangiopathy related microbleeds. AJNR R Am J Neuroradiol, 1999, 20(4): 637-642.
[8]
陈淦，周利胜，何杏玲,等.急性脑梗死与短暂性脑缺血发作的脑微出血临床特点分析.实用临床医学, 2014, 15(3): 1-4.
[9]
Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of t ransient ischemic at tack. Stroke, 2009, 40(6): 2276-2293.
[10]
刘德国，于台飞，王光彬,等.磁敏感加权成像检测脑微出血的临床价值研究.磁共振成像, 2011, 2(6): 420-425.
[11]
周星帆，王利伟，殷信道,等.磁敏感成像序列在急性大面积脑梗死并发出血中的应用.磁共振成像, 2014, 5(5): 328-331.
[12]
王绍娟，王利伟，黄海青,等.磁敏感成像序列在脑微出血诊断中的价值.磁共振成像, 2013, 4(5): 335-338.
[13]
Yakushiji Y, Noguchi T, Hara M, et al. Distributional impact of brain microbleeds on global cognitive function in adults without neurological disorder. Stroke, 2012, 43(7): 1800-1805.
[14]
Braffman B, Zimmerman R, Trojanowski J, et al. Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces. AJR Am J Roentgenol, 1988, 151(3): 551-558.
[15]
Fazekas F, Chawluk J, AlaviA, et al. MR signal abnormalities at 1.5 T in Alzheimer's dementiaand normal aging. American Journal of Roentgenology, 1987, 149(2): 351-356.
[16]
苏慧，付孟莉，孔庆奎.脑微出血与高血压的相关性分析.磁共振成像, 2015, 6(4): 266-270.
[17]
Werring D, Coward L, Losseff N, et al. Cerebral microbleeds are common in ischemic stroke but rare in TIA. Neurology, 2005, 65(12): 1914-1918.
[18]
Fluri F, Jax F, Amort M, et al. Significance of microbleeds in patients with transient ischaemic attack. Euro J Neurol, 2012, 19(3): 522-524.
[19]
Imaizumi T, Horita Y, Chiba M, et al. Dotlikehemosiderin spots on gradient echo T2-weighted magneticresonance imaging are associated with past history of small vesseldisease in patients with intracerebral hemorrhage. J Neuroimaging, 2004, 14(3): 251-257.
[20]
Jeerakathil T, Wolf PA, Beiser A, et al. Cerebral microbleeds: prevalenceand associations with cardiovascular risk factors in the framingham study. Stroke, 2004, 35(8): 1831-1835.
[21]
Lee SH, Kwon SJ, Kim KS, et al. Cerebral microbleeds in patients with hypertensive stroke. Journal of neurology, 2004, 251(10): 1183-1189.
[22]
Wieberdink RG, Poels MM, Vernooij MW, et al. Serum lipid levels and the risk of intracerebral hemorrhage: the Rotterdam Study. Arterioscler Thromb Vasc Biol, 2011, 31(12): 2982-2989.
[23]
Fan YH, Mok VC, Lam WW, et al. Cerebral microbleeds and white matter changes in patients hospitalized with lacunar infarcts. Journal of neurology, 2004, 251(5): 537-541.
[24]
Kim BJ, Lee SH, Ryu WS, et al. Low level of low-density lipoprotein cholesterol increases hemorrhagic transformation in large artery atherothrombosis but not in cardioembolism. Stroke, 2009, 40(5): 1627-1632.
[25]
Jeong SW, Jung KH, Chu K, et al. Clinical andradiological differences between primary intracerebral hemorrhagewith and without microbleeds on gradient-echo magnetic resonanceimages. Arch Neurol, 2004, 61(6): 905-909.
[26]
Knudsen KA, Rosand J, Karluk D, et al. Clinical diagnosis ofcerebral amyloid angiopathy: validation of the boston criteria. Neurology, 2001, 56(4): 537-539.
[27]
Lee SH, Kwon SJ, Kim KS, et al. Cerebral microbleedsin patients with hypertensive stroke. Topographical distribution in thesupratentorial area. J Neurol, 2004, 251(10): 1183-1189.

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