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• Clinical Article •
The pathophysiology changes and MR imaging features of high altitude heart disease in children
BAO Hai-hua  MENG Li  XIE Dong-mei 

DOI:10.3969/j.issn.1674-8034.2015.12.009.


[Abstract] Objective: To study the MRI characteristics of high altitude heart disease (HAHD) in children.Materials and Methods: Eight patients with clinically diagnosed with HAHD who lived at an elevation between 3500-4500 m, aged 8-24 months were scanned by using 0.5 T MRI equipment with ECG-gated spin-echo technique, the horizontal axis, major and minor axes were scanned as the basic levels to measure the right ventricular’s anterior wall and left ventricular’s post wall in systolic and diastolic(RVAWs and RVAWd, LVPWs and LVPWd), interventricular septum in systolic and diastolic (IVSs and IVSd) in thickness, and the diameter of pulmonary artery diameter (PAD). The six normal children who live the same sea level were measured by the same technique.Results: MRI show: (1) Eight patients were shown right ventricular wall thickening which was greater than or equal to left ventricular wall, right ventricular cavity and right atrial cavity was expanding. RVAWs was (7.35±0.84) mm, RVAWd (5.31±1.05) mm. The control of RVAWs was (3.58±0.02) mm, RVAWd was (1.98±0.12) mm. (2) Eight patients’ LVPWs was (6.18 ±0.69) mm, LVPWd (4.08±0.83) mm, one case of children increased to left ventricular wall and interventricular septum thick thickening, LVAPWd 6 mm. The control of LVPWd was (3.68± 0.30) mm. (3) The ventricular septal straight or protrude, IVSs (4.74±1.29) mm, IVSd (3.45±0.89) mm. Septal thickening The IVSd is 5.6 mm. The control IVSd was (3.17±0.46) mm. (4) Eight patients’ pulmonary artery dilation(PAD) was (17.0±1.3) mm, which is expanded compared with control subjects. The control subjects PAD is (12.15±0.51) mm.Conclusion: Right ventricular hypertrophy and pulmonary expansion was the main plateau of high altitude heart disease, with minority was left ventricular hypertrophy and ventricular septal thickening.
[Keywords] High altitude heart disease；Children；Cardiac electrophysiology；Magnetic resonance imaging

BAO Hai-hua* Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi’ning 810001, China

MENG Li Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi’ning 810001, China

XIE Dong-mei Medical Imaging Center, the Affiliated Hospital of Qinghai University, Xi’ning 810001, China

*Correspondence to: Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81260216
Received  2015-09-14
Accepted  2015-11-03
DOI: 10.3969/j.issn.1674-8034.2015.12.009
DOI:10.3969/j.issn.1674-8034.2015.12.009.

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