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• Clinical Article •
Quantitative 1H-MRS study of metabolite characteristics of autism spectrum disorders in basal ganglia regions
DAI Hai-yang  LI Qian-yi  LI Sheng-kai  XIAO Ye-yu  WU Ren-hua 

DOI:10.12015/issn.1674-8034.2017.01.003.


[Abstract] Objective: To investigate the metabolite changes in the basal ganglia regions of autistic children using 1H-MRS and LCModel.Materials and Methods: Thirteen autistic children and 14 normal developed children were enrolled in the study. MRS data were acquired in the bilateral basal regions and processed by LCModel software.Results: Compared with normal developed children, the absolute concentration of Glx, Glu and Cho in bilateral basal ganglia regions were increased with statistical significance. The ratio of Glx/Cr, Glu/Cr in bilateral basal ganglia and Cho/Cr in the right basal ganglia of autistic children was increased with statistical significance. The absolute concentration of NAA in bilateral basal ganglia of autistic children was decreased without statistical significance, while the ratio of NAA/Cr in bilateral basal ganglia was decreased with statistical significance. The absolute concentration of MI and the ratio of MI/Cr were increased in bilateral basal ganglia in autistic children without statistical significance.Conclusions: Abnormal metabolite alternation was found in the basal ganglia regions of autistic children. The increase of Glx, Glu, Cho and decrease of NAA/Cr may relate to the pathogenesis of autism.
[Keywords] Autism spectrum disorder；Magnetic resonance spectroscopy；Metabolism

DAI Hai-yang Department of Medical Imaging, Huizhou Municipal Central Hospital, Huizhou 516001, China

LI Qian-yi Department of Medical Imaging, the 8th Municipal Hospital of Dongguan, Dongguan 523326, China

LI Sheng-kai Department of Medical Imaging, Huizhou Municipal Central Hospital, Huizhou 516001, China

XIAO Ye-yu* Department of Medical Imaging, the 2nd Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

WU Ren-hua Department of Medical Imaging, the 2nd Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

*Correspondence to: Xiao YY, E-mail: xyyu73@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Medical Science and Technology Research Foundation of Guangdong Province No. A2015536 and the Key Support Project of Huizhou Municipal Central Hospital No. 2015009
Received  2016-09-28
Accepted  2016-12-07
DOI: 10.12015/issn.1674-8034.2017.01.003
DOI:10.12015/issn.1674-8034.2017.01.003.

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