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• Clinical Article •
Resting-state functional magnetic resonance imaging study of ischemic post stroke depression
ZHANG Pei-yao  XU Qin  WANG Jun  WANG Jing  DAI Jian-ping 

DOI:10.12015/issn.1674-8034.2017.06.001.


[Abstract] Objective: To investigate the altered functional connectivity (FC) of the default mode network (DMN) in patients with post ischemic stroke depression.Materials and Methods: Thirteen PSD patients and 13 matched normal controls were recruited and the resting-state fMRI images were acquired on a 3.0 T Siemens MRI scanner. The datasets were analyzed using SPM8 and REST. The bilateral precuneus were selected as regions of interest (ROIs), and functional connectivity was calculated and compared between PSD patients and normal controls.Results: The FCs of the DMN was altered in PSD patients compared to normal controls. The brain areas which showed decreased FCs including the bilateral inferior parietal lobule, bilateral frontal lobule and bilateral temporal lobule. However, the increased FC has not been found in the current study.Conclusion: Dysfunction of the DMN may be associated with the development of PSD.
[Keywords] Stroke；Depression；Default mode network；Functional connectivity；Magnetic resonance imaging, functional

ZHANG Pei-yao Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

XU Qin Department of Medical Imaging, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China

WANG Jun State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain Research, Beijing Normal University, Beijing 100875, China

WANG Jing Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

DAI Jian-ping* Department of Neuroimaging, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Dai JP, E-mail: djpbeijing@hotmail.com

Conflicts of interest   None.

Received  2017-02-27
Accepted  2017-04-15
DOI: 10.12015/issn.1674-8034.2017.06.001
DOI:10.12015/issn.1674-8034.2017.06.001.

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