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The research progress of neuroimaging studies in patients with type 2 diabetes cognitive impairment
ZHOU Yan  WANG Xiao-ming 

DOI:10.12015/issn.1674-8034.2018.05.012.


[Abstract] More than half of patients with type 2 diabetes mellitus have mild or moderate cognitive impairment, and in character with attention and memory, information processing speed and execution dysfunction and so on. In recent years, in addition to the pathophysiological studies T2DM induced mechanism of cognitive dysfunction, all kinds of new technology of MRI for revealing the structure of diabetes patient's brain and the alteration of brain function have important value, such as susceptibility weighted imaging (SWI), diffusion tensor imaging (DTI), resting-state functional magnetic resonance imaging (rs-fMRI), magnetic resonance spectroscopy (MRS), etc, play an important role in revealing the changes of brain structure and function in diabetes. In this article, we present a review focusing on neurological imaging of brain structure and function changes in patients with T2DM.
[Keywords] Brain Injury, chronic;Diabetes mellitus, Type 2;Cognition disorders;Magnetic resonance imaging

ZHOU Yan Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

WANG Xiao-ming* Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

*Corresponding to: Wang XM, E-mail: wangxm024@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of the National Natural Science Foundation of China No. 81471720 Basic Research Project of Key Laboratory of Educationg Department of Liaoning Province No. LZ2014039 Outstanding Scientific Fund of Shengjing Hospital No. 201402
Received  2017-12-21
Accepted  2018-03-11
DOI: 10.12015/issn.1674-8034.2018.05.012
DOI:10.12015/issn.1674-8034.2018.05.012.

[1]
Mccrimmon RJ, Ryan CM, Frier BM. Diabetes and cognitive dysfunction. Lancet, 2012, 379(9833): 2291-2299.
[2]
Moran C, Forbes JM, Beare R, et al. Type 2 diabetes, skin autofluorescence and brain atrophy. Diabetes, 2015, 64 (1): 279-283.
[3]
Biessels GJ, Reijmer YD. Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes, 2014, 63(7): 2244-2252.
[4]
Ryan JP, Fine DF, Rosano C. Type 2 diabetes and cognitive impairment: contributions from neuroimaging. Geriatr Psychiatry Neurol, 2014, 27(1): 47-55.
[5]
Moulton CD, Costafreda SG, Horton P, et al. Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes. Brain Imaging Behav, 2015, 9(4): 651-662.
[6]
Roberts RO, Knopman DS, Przybelski SA, et al. Association of type 2 diabetes with brain atrophy and cognitive impairment. Neurology, 2014, 82(13): 1132-1141.
[7]
Qu H, Gao JY, Li C, et al. Regional neural activity homogeneity and anatomical brain alterations in type 2 diabetes. J Clin Radiol, 2016, 35(14): 512-517.
[8]
Chung CC, Pimentel D, Jor'dan AJ, et al. Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes. Neurology, 2015, 85(5): 450-458.
[9]
Umemura T, Kawamura T, Hotta N. Pathogenesis and neuroimaging of cerebral large and small vessel disease in type 2 diabetes: A possible link between cerebral and retinal microvascular abnormalities. J Diabetes Investig, 2017, 8 (2): 134-148.
[10]
Venkat P, Chopp M, Chen J. Blood-brain barrier disruption, vascular impairment, and ischemia/Reperfusion damage in diabetic stroke. J Am Heart Assoc, 2017, 6 (6): e005819.
[11]
Cordonnier C, Salman AS, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain, 2007, 130(8): 1988-2003.
[12]
熊婧彤,苗强,伍建林,等.磁敏感加权成像检测糖尿病患者脑微出血及其与认知功能的相关性.中国医学影像技术, 2015, 31(12): 1792-1796.
[13]
Muñoz-Rivas N, Méndez-Bailón M, Hernández-Barrera V, et al. Time trends in ischemic stroke among type 2 diabetic and non-diabetic patients: analysis of the spanish national hospital discharge data (2003-2012). Plos One, 2015, 10(12): e0145535.
[14]
Edwards JD, Jacova C, Sepehry AA, et al. A quantitative systematic review of domain-specific cognitive impairment in lacunar stroke. Neurology, 2013, 80(3): 315-322.
[15]
Last D, Alsop DC, Abduljalil AM, et a1. Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care, 2007, 30(5): 1193-1199.
[16]
Beason-Held LL, Thambisetty M, Deib G, et al. Baseline cardiovascular risk predicts subsequent changes in resting brain function. Stroke, 2012, 43(6): 1542-1547.
[17]
Thambisetty M, Beasonheld LL, An Y, et al. Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging. Neurobiol Aging, 2013, 34(10): 2271-2276.
[18]
Rusinek H, Ha J, Yau PL, et al. Cerebral perfusion in insulin resistance and type 2 diabetes. J Cereb Blood Flow Metab, 2015, 35(1): 95-102.
[19]
Cui Y, Liang X, Gu H, et al. Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction. Brain Imaging Behav, 2017, 11(5): 1248-1257.
[20]
王善诚,李澄,瞿航.磁共振灌注加权成像在糖尿病脑损害中的应用进展.磁共振成像, 2017, 8(2): 155-160.
[21]
Falvey CM, Rosano C, Simonsick EM, et al. Macro- and microstructural magnetic resonance imaging indices associated with diabetes among community-dwelling older adults. Diabetes Care, 2013, 36(3): 677-682.
[22]
Hsu JL, Chen YL, Leu JG, et al. Microstructural white matter abnormalities in type 2 diabetes mellitus: a diffusion tensor imaging study. Neuroimage, 2012, 59(2): 1098-1105.
[23]
Yau PL, Kluger A, Borod JC, et al. Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus. J Clin Exp Neuropsychol, 2014, 36(1): 74-87.
[24]
Mansur RB, Cha DS, Woldeyohannes HO, et al. Diabetes mellitus and disturbances in brain connectivity: a bidirectional relationship? Neuromolecular Med, 2014, 16 (4): 658-668.
[25]
Cui Y, Jiao Y, Chen HJ, et al. Aberrant functional connectivity of default-mode network in type 2 diabetes patients. Eur Radiol, 2015, 25(11): 3238-3246.
[26]
Musen G, Jacobson AM, Bolo NR, et al. Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes, 2012, 61(9): 2375-2379.
[27]
Cui Y, Jiao Y, Chen YC, et al. Altered spontaneous brain activity in type 2 diabetes: a resting-state functional MRI study. Diabetes, 2014, 63(2): 749-760.
[28]
Xia W, Wang S, Sun Z, et al. Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study. Psychoneuroendocrinology, 2013, 38(11): 2493-2501.
[29]
Xia W, Chen YC, Ma J. Resting-state brain anomalies in type 2 diabete. Frontiers Aging Neurosci, 2017, 9: 14.
[30]
Sun DM, Ma Y, Sun ZB, et al. Decision-making in primary onset middle-age type 2 diabetes mellitus: a BOLD-fMRI study. Sci Rep, 2017, 7(1): 10246.
[31]
Sinha S, Ekka M, Sharma U, et a1. Assessment of changes in brain metabolites in Indian patients with type-2 diabetes mellitus using proton magnetic resonance spectroscopy. BMC Res Notes, 2014, 7(1): 1-7.
[32]
Hajek T, Calkin C, Blagdon R, et a1. Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders. Biol Psychiatry, 2015, 77(3): 295-303.
[33]
Wang Y, Xu XY, Feng CH, et al. Patients with type 2 diabetes exhibit cognitive impairment with changes of metabolite concentration in the left hippocampus. Metab Brain Dis, 2015, 30(4): 1027-1034.
[34]
张秋娟,戴晓庆,宫琰,等. 2型糖尿病患者大脑后扣带回谷氨酸代谢的磁共振波谱研究.实用放射学杂志, 2016, 32(9): 1344-1347.
[35]
Wu GY, Zhang Q, Wu JL, et al. Changes in cerebral metabolites in type 2 diabetes mellitus: A meta-analysis of proton magnetic resonance spectroscopy. J Clin Neurosci, 2017, 45(11): 9-13.

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