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• Clinical Article •
Assessing difference in brain function between heroin dependents after one year methadone maintenance treatment and protracted abstinence: A resting-state fMRI study
LIU Wei  CHEN Jiajie  SHI Hong  XUE Jiuhua  LI Wei  LI Yongbin  LIU Yan  WANG Wei  LI Qiang 

Cite this article as: Liu W, Chen JJ, Shi H, et al. Assessing difference in brain function between heroin dependents after one year methadone maintenance treatment and protracted abstinence: A resting-state fMRI study. Chin J Magn Reson Imaging, 2019, 10(12): 890-894. DOI:10.12015/issn.1674-8034.2019.12.003.


[Abstract] Objective: To investigate the difference in effect of one year protracted abstinence and the methadone maintenance treatment on brain function in heroin addicts.Materials and Methods: Seventeen heroin dependent patients during abstinence (PA group), 16 heroin dependent patients during methadone maintenance treatment (MMT group) and 35 healthy control group (HC group) were enrolled in this study. The resting-state data were collected by functional magnetic resonance scanning (fMRI). The intensity of local spontaneous brain activity in the three groups was calculated by the amplitude of low frequency fluctuation (ALFF) method. The variance analysis and post-event analysis were used to compare the changes of brain activity between PA group and MMT group.Results: There were significant differences in ALFF values in the right calcarine gyrus, the left superior cerebellar gyrus, the right medial superior frontal gyrus and the right supplementary motor area among the three groups. The brain activity in the calcarine gyrus and the supplementary motor area in the PA group was closer to the normal group. The ALFF value of the right medial frontal gyrus of the MMT group was negatively correlated with the methadone maintenance treatment time (month) (r=-0.67, P=0.004), and the right margin of the PA group was ALFF and the forced withdrawal time (month) was negatively correlated (r=-0.54, P=0.02).Conclusions: After one year of intervention, there are still abnormalities in some brain areas of heroin addicts in methadone maintenance therapy and protracted abstinence, but protracted abstinence may be more conducive to the recovery of brain function in heroin addicts.
[Keywords] protracted abstinence；methadone；addiction；heroin；low frequency amplitude

LIU Wei Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

CHEN Jiajie Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

SHI Hong Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

XUE Jiuhua Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

LI Wei Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

LI Yongbin Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

LIU Yan Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

WANG Wei Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

LI Qiang * Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China

*Correspondence to: Li Q, E-mail: tdqiangqiang@foxmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671661
Received  2019-08-14
DOI: 10.12015/issn.1674-8034.2019.12.003
Cite this article as: Liu W, Chen JJ, Shi H, et al. Assessing difference in brain function between heroin dependents after one year methadone maintenance treatment and protracted abstinence: A resting-state fMRI study. Chin J Magn Reson Imaging, 2019, 10(12): 890-894. DOI:10.12015/issn.1674-8034.2019.12.003.

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