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• Clinical Article •
Preliminary study of DSC-MRI and IVIM in differentiating postoperative recurrence and radiation brain injury of high-grade glioma
SHAN Manyu  YANG Guoqiang  QIN Jiangbo  ZHANG Hui 

Cite this article as: Shan MY, Yang GQ, Qin JB, et al. Preliminary study of DSC-MRI and IVIM in differentiating postoperative recurrence and radiation brain injury of high-grade glioma. Chin J Magn Reson Imaging, 2020, 11(5): 326-331. DOI:10.12015/issn.1674-8034.2020.05.002.


[Abstract] Objective: To investigate the dynamic susceptibility weighted contrast enhanced (DSC-MRI) and intravoxel incoherent motion (IVIM) of magnetic resonance imaging in differentiating high-grade glioma recurrence and radiation brain injury.Materials and Methods: Thirty-two patients with high-grade gliomas who underwent postoperative resection and concurrent chemoradiotherapy and MRI were collected, and new abnormally enhanced lesions appeared in the MRI imaging. According to the results of the second operation or follow- up, they were divided into tumor recurrence group (n=22) and radiation brain injury group (n=10). Measure the relative cerebral blood volume (rCBV), pure diffusion coefficient (D), perfusion related diffusion coefficient (D*), and perfusion fraction (f) and other parameters. The independent sample t test was used to analyze the differences between the two groups, and the receiver operating characteristic (ROC) curve was plotted and the area under the curve, sensitivity, and specificity were calculated; and the correlation between the parameters was analyzed using the Pearson test.Results: The rCBV value, D* value, and f value of the relapse group were higher than those of the radiation brain injury group, and the difference was statistically significant (P<0.05). The D value of the relapse group was lower than that of the radiation brain injury group, and the difference was statistically significant (P<0.05), ROC curve analysis, rCBV value, D value, D* value, area under the f value curve are 0.832, 0.709, 0.814, 0.780, sensitivity is 72.7%, 86.4%, 81.8%, 95.5%, specificity is 90.0%, 50.0%, 80.0%, 50.0%. When DSC-MRI combined with IVIM was diagnosed, the area under the curve was 0.891, and the sensitivity and specificity were 81.8% and 90.0%, respectively; the D* value (r=0.542, P<0.05), and the f-value (r=0.352, P<0.05), there is a positive correlation with the rCBV value.Conclusions: DSC-MRI combined with IVIM has important clinical application value in the differential diagnosis of glioma recurrence and radiation brain damage, and there is a certain correlation between rCBV value and D*, f value.
[Keywords] magnetic resonance imaging；glioma；postoperative recurrence；brain radiation injury

SHAN Manyu College of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

YANG Guoqiang Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China

QIN Jiangbo Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China

ZHANG Hui* Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China

*Correspondence to: Zhang H, E-mail: zhanghui_mr@163.com

Conflicts of interest   None.

Received  2019-12-31
Accepted  2020-03-26
DOI: 10.12015/issn.1674-8034.2020.05.002
Cite this article as: Shan MY, Yang GQ, Qin JB, et al. Preliminary study of DSC-MRI and IVIM in differentiating postoperative recurrence and radiation brain injury of high-grade glioma. Chin J Magn Reson Imaging, 2020, 11(5): 326-331. DOI:10.12015/issn.1674-8034.2020.05.002.

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