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• Clinical Article •
Application of mTI-ASL technique in differentiating recurrence from radiation injury of brain glioma after operation
BAI Xuefei  GAO Yang  NIU Guangming  WU Qiong  WANG Shaoyu  ZHANG Huapeng 

Cite this article as: Bai XF, Gao Y, Niu GM, et al. Application of mTI-ASL technique in differentiating recurrence from radiation injury of brain glioma after operation. Chin J Magn Reson Imaging, 2020, 11(5): 332-335. DOI:10.12015/issn.1674-8034.2020.05.003.


[Abstract] Objective: In this study, we use multiple inversion time-pulsed arterial spin labeling (mTI-ASL) technique to quantitatively analyze the difference between recurrence and radiation injury of glioma after operation, to further evaluate the value of mTI-ASL technique in differential diagnosis between recurrence and radiation injury of glioma.Materials and Methods: In this study, 20 cases of glioma recurrence, 10 cases of radiation injury subjects were collected. We used Siemens 3.0 T Skyra scanner to collect, mTI-ASL sequence was performed on a 3.0 T MR scanner (Magnetom Skyra, Siemens Healthcare, Erlangen, Germany) after surgery and radiotherapy in patients with glioma. The original image of mTI-ASL was post processed on MATLAB software to obtain CBF and ATT maps. The region of interest was delineated manually by using MRI cron soft ware. Independent sample t-test was used to compare the parameters of the region of interest (ROI) related to recurrence and radiation injury of glioma after operation, and to evaluate the difference of CBF and ATT values of quantitative parameters, so as to evaluate the ability of mTI-ASL technology to differentiate the two parameters.Results: (1) CBF values of recurrence after glioma surgery (6.38±1.41) were higher than those of radiation injury (2.30±0.37). There was significant difference between them (P<0.01). (2) ATT values of recurrence after glioma surgery (0.19±0.30) were higher than the CBF values of radiation injury (0.16±0.12), and the difference was statistically significant (P<0.01).Conclusions: The mTI-ASL technique can distinguish the recurrence and radiation injury of glioma after operation.
[Keywords] magnetic resonance imaging；glioma；postoperative recurrence；brain radiation injury

BAI Xuefei Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China

GAO Yang Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China

NIU Guangming Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China

WU Qiong Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China

WANG Shaoyu Siemens Healthineers, Shanghai 201318, China

ZHANG Huapeng Siemens Healthineers, Shanghai 201318, China

*Correspondence to: Gao Y, E-mail: 1390903990@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Science Research Project of Inner Mongolia Medical University in 2019 No. NJZY19105 Inner Mongolia Natural Science Foundation Project No. 2018MS08078 Science and Technology Program of Inner Mongolia Autonomous Region No. 2019GG047
Received  2019-09-30
Accepted  2020-03-26
DOI: 10.12015/issn.1674-8034.2020.05.003
Cite this article as: Bai XF, Gao Y, Niu GM, et al. Application of mTI-ASL technique in differentiating recurrence from radiation injury of brain glioma after operation. Chin J Magn Reson Imaging, 2020, 11(5): 332-335. DOI:10.12015/issn.1674-8034.2020.05.003.

[1]
Mao Y, Yao Y, Zhang LW, et al. Does early postsurgical temozolomide plus concomitant radiochemotherapy regimen have any benefit in newly-diagnosed glioblastoma patients? A multicenter,randomized,paral lel,open-label, phase II clinical trial. Chin Med J (Engl), 2015, 128(20): 2751-2758.
[2]
Shin KE, Ahn KJ, Choi HS, et al. DCE and DSC MR perfusion imaging in the differentiation of recurrent tumour from treatment-related changes in patients with glioma. Clin Radiol, 2014, 69(6): e264-272.
[3]
Blasel S, Zagorcic A, Jurcoane A, et al. Perfusion MRI in the evaluation of suspected glioblastoma recurrence. J Neuroimaging, 2016, 26(1): 116-123.
[4]
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med, 1971, 285(21): 1182-1186.
[5]
Ye J, Bhagat SK, Li H, et al. Differentiation between recurrent gliomas and radiation necrosis using arterial spin labeling perfusion imaging. Exp Ther Med, 2016, 11(6): 2432-2436.
[6]
Wan B, Wang S, Tu M, et al. The diagnostic performance of perfusion MRI for differentiating glioma recurrence from pseudoprogression. Medicine (Baltimore), 2017, 96(11): e6333.
[7]
潘锋，诸一吕，姚丽娣,等. 3D-ASL技术在高级别脑胶质瘤术后复发诊断与鉴别诊断中的应用．医学影像学杂志, 2018, 28(8): 1234-1237.
[8]
白雪冬，孙夕林，王丹,等．动态对比增强MRI在鉴别胶质瘤复发及放射性脑损伤中的应用．磁共振成像, 2014, 5(1): 1-6.
[9]
Kim TH, Yun TJ, Park CK, et al. Combined use of susceptibility weighted magnetic resonance imaging sequences and dynamic susceptibility contrast perfusion weighted imaging to improve the accuracy of the differential diagnosis of recurrence and radionecrosis in high-grade glioma patients. Oncotarget, 2016, 11(3): 20340-20353.
[10]
王筝，傅雪梅，曾祥柱,等．基于3D动脉自旋标记技术核磁灌注成像中动脉通过时间的研究．中国医疗设备, 2015, 30(9): 24-26.
[11]
Hong Rye Kim, Se-Hwan Kim, Jung-I, et al. Outcome of radiosurgery for recurrent malignant gliomas:assessment of treatment response using relative cerebral blood volume. J Neuro Oncol, 2014, 121(2): 311-318.
[12]
Amukotuwa SA, Yu C, Zaharchuk G. 3D Pseudocontinuous arterial spin labeling in routine clinical practice: a review of clinically significant artifacts. J Magn Reson Imaging, 2015, 43(1): 11-27.
[13]
杨双．多参数多相位动脉自旋标记成像技术在脑星形细胞瘤中的应用．济南:山东大学, 2016.

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