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3.0 T MRI double-echo hydro-lipid separation Dixon technique for quantitative determination of liver fat in patients with nonalcoholic fatty liver disease
YING Jie  LIU Dan  YANG Quan  WANG Xinglan  DING Zhaojun  SU Liping 

Cite this article as: Ying J, Liu D, Yang Q, et al. 3.0 T MRI double-echo hydro-lipid separation Dixon technique for quantitative determination of liver fat in patients with nonalcoholic fatty liver disease. Chin J Magn Reson Imaging, 2020, 11(7): 577-580. DOI:10.12015/issn.1674-8034.2020.07.020.


[Abstract] Objective: To study the liver fat content in patients with fatty liver by using magnetic resonance water-fat separation Dixon method, and to explore the feasibility and clinical value of the quantitative analysis of the liver fat in the non-alcoholic hepatic steatosis.Materials and Methods: Dixon technique (T1-VIBE-Dixon), a phase (in-phase, IP) and (out-phase, OP) and MRS image were obtained by using conventional liver MRI plain scan and double-echo water-fat separation Dixon technique (T1-VIBE-Dixon). The obtained sequence of Dixon scan obtained the fat fraction map by the software, and the fat score map and the magnetic resonance spectroscopy (MRS) sequence were statistically analyzed for their correlation by the fat fraction (FF) measured at the same position.Results: The correlation coefficient between the FF value measured by the T1-VIBE-Dixon sequence and the FF value measured by 1H-MRS is as high as 0.99637, which is highly correlated.Conclusions: It is feasible to use 3.0 T MRI double-echo water-fat separation Dixon technique in the quantitative analysis of the liver fat in non-alcoholic liver steatosis, and the result is valuable for the diagnosis, follow-up and monitoring of non-alcoholic fatty liver.
[Keywords] Nonalcoholic fatty liver disease；magnetic resonance imaging；Dixon technique；quantitative analysis

YING Jie Department of Radiology, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402160, China

LIU Dan* Department of Radiology, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402160, China

YANG Quan Department of Radiology, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402160, China

WANG Xinglan Department of Radiology, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402160, China

DING Zhaojun Department of Radiology, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402160, China

SU Liping Department of Radiology, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402160, China

*Corresponding to: Liu D, E-mail: 65677676@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by Chongqing Municipal Health and Family Planning Commission Medical Research Project No. 2017MSXMO77
Received  2019-10-29
Accepted  2020-03-25
DOI: 10.12015/issn.1674-8034.2020.07.020
Cite this article as: Ying J, Liu D, Yang Q, et al. 3.0 T MRI double-echo hydro-lipid separation Dixon technique for quantitative determination of liver fat in patients with nonalcoholic fatty liver disease. Chin J Magn Reson Imaging, 2020, 11(7): 577-580. DOI:10.12015/issn.1674-8034.2020.07.020.

[1]
Lidia S, Szczepaniak L, Pamela Nurenberg P, et al. Magneticresonance spectroscopy to measure hepatic hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Ame J Phsiol Endocrinol Metab, 2005(288): 462-468.
[2]
Polyzos SA, Mantzoros CS. Necessity for timely noninvasive diagnosis of nonalcoholic fatty liver disease. Metabol Clin Exper, 2013, 63(2): 161-167.
[3]
El-Kader SM, Ashmawy ED. Non-alcoholic fatty liver disease: the diagnosis andmanagement. World J Hepatol, 2015, 7(6): 846-858.
[4]
中华肝脏病学会脂肪肝和酒精性肝病学组．非酒精性肝病诊断标准.中华肝脏病杂志, 2003, 7(2): 428-429.
[5]
中华肝脏病学会脂肪肝和酒精性肝病学组．酒精性脂肪性肝病诊断标准．中华肝脏病杂志, 2006, 11(2): 72.
[6]
Neuschwander-Tetri BA, Caldwell H. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology, 2003, 37(5): 1202-1219.
[7]
黄梦月．大鼠非酒精性脂肪肝的IDEAL-IQ和MRS评价．郑州：郑州大学, 2016.
[8]
Bedogni G, Kahn HS, Bellentani S, et al. A simple index of lipid overaccumulation is a good marker of liversteatosis. BMC Gastroenterol, 2010, 10: 98.
[9]
张瑛．瞬时弹性成像技术FAI值对非酒精性脂肪肝及其分级诊断的价值．影像研究与医学应用, 2019, 3(10): 106-107.
[10]
Runge JH, Smits LP, Verheij J，等. MR波谱成像衍生的质子密度脂肪分数检测和评估肝脏脂肪变性分级的价值优于受控衰减参数．国际医学放射学杂志, 2018, 41(2): 227-228.
[11]
吕晓婷．非酒精性脂肪肝患者IDEAL-IQ与MRS定量评估及比较．郑州：郑州大学, 2016.
[12]
王嫚．应用Dixon方法对非酒精性脂肪肝及初诊2型糖尿病肝脏脂肪沉积的量化分析．合肥：安徽医科大学, 2018.
[13]
Szczepaniak LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. J Endocrinol Metabol, 2005, 288(2): e462-e468.
[14]
D'Assignies G, Ruel M, Khiat A, et al. Noninvasive quantitation of human liver steatosis using magnetic resonance and bioassay methods. Eur Radiol, 2009, 19(8): 2033-2040.
[15]
赵黎明，宋彬，陈光文，等. 3.0 T 1-H MRS和梯度回波化学位移MRI在定量分析肝脏脂肪含量的价值．实用放射学杂志, 2010, 6(10): 1452-1456.
[16]
Krishan S, Jain D, Bathina Y, et al. Non-invasive quantification of hepatic steatosis in living, related liver donors using dual-echo Dixon imaging and single-voxel proton spectroscopy. Clin Radiol, 2016, 71(1): 58-63.
[17]
Dixon WT. Simple proton spectroscopy imaging. Radiology, 1984, 153(1): 189-194.
[18]
Johnson BL, Schroeder ME, Wolfson T, et al. Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data-based, T1-independent, T2*-corrected, spectrum-modeled MRI. J Magn Reson Imaging, 2014, 39(2): 440-447.
[19]
Yokoo T, Bydder M, Hamilton G, et al. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of lowflip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology, 2009, 251(1): 67-76.
[20]
Régis A, Guiu B, Walker PM, et al. Bone marrow fat quantification of osteoporotic vertebral compression fractures:comparison of multi-voxel proton MR Bone marrow fat quantifi cation of osteoporotic vertebral compression fractures:comparison of multivoxel proton MR spectroscopy and chemical-shift gradient-echo MR imaging. Acta Radiol, 2011, 52(9): 1032-1036.
[21]
郭若汨，唐文杰，朱叶青，等．磁共振IDEAL-IQ序列对肝脏脂肪变性和铁过载的诊断价值．中山大学学报（医学科学版）, 2015, 36(5): 689-692.
[22]
Dixon WT. Simple proton spectroscopy imaging. Radiology, 1984, 153(1): 189-194.
[23]
Sumida Y, Nakajima A, Hoh Y. Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol, 2014, 20(2): 475-485.

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