Share：
Share this content in WeChat
X
[Chinese][PDF]858113
• Review •
Application situation and progress of amide proton transfer imaging in central nervous system
WANG Ruru  LI Qilin  TIAN Weiwei  WANG Xinyu  JIANG Xingyue 

Cite this article as: Wang RR, Li QL, Tian WW, et al. Application situation and progress of amide proton transfer imaging in central nervous system. Chin J Magn Reson Imaging, 2020, 11(12): 1194-1197. DOI:10.12015/issn.1674-8034.2020.12.027.


[Abstract] Amide proton transfer (APT) imaging is a rapidly developed and mature method in chemical exchange saturation transfer imaging, based on the theory of magnetization transfer and chemical exchange, APT imaging assays changes in intracellular protein concentration and pH by detecting the rate at which amide-protons on free proteins and polypeptide chains exchange with hydrogen ions in water. As a non-invasive cellular molecular level magnetic resonance technique, APT imaging can provide important imaging information in brain injury, brain tumor, neurodegenerative disease and brain development in children, and provide help for clinical diagnosis, treatment and prognosis. This paper mainly describes the application status and progress of APT imaging in the central nervous system.
[Keywords] amide proton transfer；magnetic resonance imaging；protein；pH；central nervous system

WANG Ruru Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China

LI Qilin Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China

TIAN Weiwei Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China

WANG Xinyu Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China

JIANG Xingyue* Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China

*Correspondence to: Jiang XY, E-mail: xyjiang188@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Shandong Province Natural Science Found No.ZR2018LH015
Received  2020-07-13
Accepted  2020-08-21
DOI: 10.12015/issn.1674-8034.2020.12.027
Cite this article as: Wang RR, Li QL, Tian WW, et al. Application situation and progress of amide proton transfer imaging in central nervous system. Chin J Magn Reson Imaging, 2020, 11(12): 1194-1197. DOI:10.12015/issn.1674-8034.2020.12.027.

[1]
Zhou J, Lal B, Wilson DA, et al. Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med, 2003, 50(6): 1120-1126. DOI: 10.1002/mrm.10651.
[2]
Van Zijl PC, Zhou J, Mori N, et al. Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids. Magn Reson Med, 2003, 49(3): 440-449. DOI: 10.1002/mrm.10398.
[3]
Van Zijl PC, Yadav NN. Chemical exchange saturation transfer (CEST): what is in a name and what isn't?. Magn Reson Med, 2011, 65(4): 927-948. DOI: 10.1002/mrm.22761.
[4]
Vinogradov E, Sherry AD, Lenkinski RE. CEST: from basic principles to applications, challenges and opportunities. J Magn Reson, 2013, 229(4): 155-172. DOI: 10.1016/j.jmr.2012.11.024.
[5]
Zheng Y, Wang X, Zhao X. Magnetization transfer and amide proton transfer MRI of neonatal brain development. Biomed Res Int, 2016, 2016: 3052723. DOI: 10.1155/2016/3052723.
[6]
Zhang H, Kang H, Zhao X, et al. Amide proton transfer (APT) MR imaging and magnetization transfer (MT) MR imaging of pediatric brain development. Eur Radiol, 2016, 26(10): 3368-3376. DOI: 10.1007/s00330-015-4188-z.
[7]
Zhang Z, Zhang C, Yao J, et al. Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla. Quant Imaging Med Surg, 2020, 10(3): 727-742. DOI: 10.21037/qims.2020.02.22.
[8]
郑阳，王晓明.新生猪缺氧缺血脑损伤后酰胺质子转移成像.中国医学影像技术, 2017, 33(8): 1153-1157. DOI: 10.13929/j.1003-3289.201611080.
[9]
郑阳，王晓明.磁化传递成像和酰胺质子转移成像联合评价新生儿脑损伤的初步研究.磁共振成像, 2017, 8(3): 189-195. DOI: 10.12015/issn.1674-8034.2017.03.006.
[10]
陈思瑾.磁共振酰胺质子转移成像在新生儿缺血缺氧性脑损伤诊断中的应用价值.广州:南方医科大学, 2019.
[11]
Sun PZ, Zhou J, Sun W, et al. Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab, 2007, 27(6): 1129-1136. DOI: 10.1038/sj.jcbfm.9600424.
[12]
Huang D, Li S, Dai Z, et al. Novel gradient echo sequence based amide proton transfer magnetic resonance imaging in hyperacute cerebral infarction. Mol Med Rep, 2015, 11(5): 3279-3284. DOI: 10.3892/mmr.2015.3165.
[13]
张帅，李春媚，宋国栋,等.酰胺质子转移磁共振成像在缺血性脑梗死分期中的应用.山东医药, 2016, 56(43): 52-54. DOI: 10.3969/j.issn.1002-266X.2016.43.016.
[14]
Yu L, Chen Y, Chen M, et al. Amide proton transfer MRI signal as a surrogate biomarker of ischemic stroke recovery in patients with supportive treatment. Front Neurol, 2019, 10: 104. DOI: 10.3389/fneur.2019.00104.
[15]
Sun PZ, Cheung JS, Wang E, et al. Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke. J Cereb Blood Flow Metab, 2011, 31(8): 1743-1750. DOI: 10.1038/jcbfm.2011.23.
[16]
Zhou J, van Zijl PC. Defining an acidosis-based ischemic penumbra from pH-weighted MRI. Transl Stroke Res, 2011, 3(1): 76-83. DOI: 10.1007/s12975-011-0110-4.
[17]
Harston GW, Tee YK, Blockley N, et al. Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. Brain, 2015, 138(Pt 1): 36-42. DOI: 10.1093/brain/awu374.
[18]
谭月发.旋转坐标系下时间常数(T1ρ)和表观扩散系数(ADC)在评估缺血性脑卒中演变进程中的对比应用&酰胺质子转移成像(APT)和动脉自旋标记(ASL)联合评价亚急性脑梗中缺血半暗带的初步研究.广州:南方医科大学, 2018.
[19]
Yan K, Fu Z, Yang C, et al. Assessing amide proton transfer (APT) MRI contrast origins in 9 L gliosarcoma in the rat brain using proteomic analysis. Mol Imaging Biol, 2015, 17(4): 479-487. DOI: 10.1007/s11307-015-0828-6.
[20]
Debnath A, Gupta RK, Singh A. Evaluating the role of amide proton transfer (APT)-weighted contrast, optimized for normalization and region of interest selection, in differentiation of neoplastic and infective mass lesions on 3 T MRI. Mol Imaging Biol, 2020, 22(2): 384-396. DOI: 10.1007/s11307-019-01382-x.
[21]
Chen Y, Li X, Song Y, et al. The diagnostic efficacy of amide proton transfer imaging in grading gliomas and predicting tumor proliferation. Neuroreport, 2019, 30(2): 139-144. DOI: 10.1097/WNR.0000000000001174.
[22]
Joo B, Han K, Ahn SS, et al. Amide proton transfer imaging might predict survival and IDH mutation status in high-grade glioma. Eur Radiol, 2019, 29(12): 6643-6652. DOI: 10.1007/s00330-019-06203-x.
[23]
Jiang S, Eberhart CG, Lim M, et al. Identifying recurrent malignant glioma after treatment using amide proton transfer-weighted MR imaging: A validation study with image-guided stereotactic biopsy. Clin Cancer Res, 2019, 25(2): 552-561. DOI: 10.1158/1078-0432.CCR-18-1233.
[24]
Jiang S, Yu H, Wang X, et al. Molecular MRI differentiation between primary central nervous system lymphomas and high-grade gliomas using endogenous protein-based amide proton transfer MR imaging at 3 Tesla. Eur Radiol, 2016, 26(1): 64-71. DOI: 10.1007/s00330-015-3805-1.
[25]
Yu H, Lou H, Zou T, et al. Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma. Eur Radiol, 2017, 27(11): 4516-4524. DOI: 10.1007/s00330-017-4867-z.
[26]
Kamimura K, Nakajo M, Yoneyama T, et al. Histogram analysis of amide proton transfer-weighted imaging: comparison of glioblastoma and solitary brain metastasis in enhancing tumors and peritumoral regions. Eur Radiol, 2019, 29(8): 4133-4140. DOI: 10.1007/s00330-018-5832-1.
[27]
陈莉，王开平，孙先普,等. PWI鉴别诊断单发脑转移瘤和高级别胶质瘤的价值分析.医学影像学杂志, 2018, 28(12): 1966-1970.
[28]
Li C, Peng S, Wang R, et al. Chemical exchange saturation transfer MR imaging of Parkinson's disease at 3 Tesla. Eur Radiol, 2014, 24(10): 2631-2639. DOI: 10.1007/s00330-014-3241-7.
[29]
王蕊，班允清，李春媚,等.阿尔茨海默病脑磁共振氨基质子转移成像与临床心理量表评分的相关性研究.磁共振成像, 2018, 9(3): 161-165. DOI: 10.12015/issn.1674-8034.2018.03.001.
[30]
王蕊，陈涓，李春媚,等.阿尔茨海默病和轻度认知功能障碍患者的磁共振酰胺质子转移成像初步研究.中华老年医学杂志, 2015, 34(10): 1080-1083. DOI: 10.3760/cma.j.issn.0254-9026.2015.10.008.
[31]
Wang R, Chen P, Shen Z, et al. Brain amide proton transfer imaging of rat with Alzheimer's disease using saturation with frequency alternating RF irradiation method. Front Aging Neurosci, 2019, 11: 217. DOI: 10.3389/fnagi.2019.00217.

PREV A case of fallopian tube carcinosarcoma misdiagnosed as ovarian cancer on MR
NEXT Application of magnetic resonance mapping technology in the differentiation of left ventricular hypertrophic diseases
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn