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• CLINICAL ARTICLE •
3D-ASL assessment of cerebral blood flow changes in chronic stroke patients
MIAO Peifang  WANG Caihong  WEI Ying  WU Luobing  WANG Yingying  GUO Yafei  LI Peng  CHENG Jingliang 

Cite this article as: Miao PF, Wang CH, Wei Y, et al. 3D-ASL assessment of cerebral blood flow changes in chronic stroke patients[J]. Chin J Magn Reson Imaging, 2021, 12(2): 1-5. DOI:10.12015/issn.1674-8034.2021.02.001.


[Abstract] Objective To evaluate resting-state cerebral blood flow (CBF) and the relationship between cerebral blood flow and cognitive function in well-recovered patients 6 months after subcortical ischemic stroke used 3D arterial spin labeling (3D-ASL) imaging. Materials andMethods A total of 29 well-recovered patients 6 months after subcortical ischemic stroke patients and 30 healthy subjects were investigated to undergo 3D arterial spin labeling (3D-ASL) using GE Discovery MR 750 3.0 Tesla MR scanner and behavioral tasks. The CBF maps were processing via SPM8 in Matlab. The GLM was applied to quantitatively compare group differences in CBF throughout the whole brain with age, gender and the years of education as covariates of no interest with SPM8. Moreover, we performed partial correlation analysis to investigate the association between the clinical behavior scores and the statistics results of CBF with SPSS 17.0.Results The voxel-wise analysis showed that the well-recovered stroke patients exhibited increased CBF in contralesional superior frontal gyrus (SFG) and supramarginal gyrus (SMG) compared with normal controls (P＜0.05, cluster size＞1054 voxels). Moreover, the increased CBFs of the contralesional SFG (r=-0.41, P=0.037), and supramarginal gyrus (SMG) (r=-0.42, P=0.036) were all significant negative correlation with TMT-B.Conclusions We identified cerebral blood flow altered in the contralesional hemisphere in the subcortical stroke patients with well-recovery global motor function. Moreover, increased CBF were correlated with cognitive functional may represent a compensatory reorganization for the cognitive functional decline of subcortical stroke patients.
[Keywords] stroke；functional magnetic resonance imaging；cerebral blood flow；cognitive function；arterial spin labeling

MIAO Peifang1   WANG Caihong1   WEI Ying1   WU Luobing1   WANG Yingying1   GUO Yafei2   LI Peng3   CHENG Jingliang1*  

1 Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China

2 Department of Radiology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China

3 Department of Radiology, Henan Cancer Hospital, Zhengzhou 450000, China

Cheng JL, E-mail: cjr.chjl@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGENTS This work was part of National Natural Science Foundation of China (No.81601467).
Received  2020-09-29
Accepted  2021-01-11
DOI: 10.12015/issn.1674-8034.2021.02.001
Cite this article as: Miao PF, Wang CH, Wei Y, et al. 3D-ASL assessment of cerebral blood flow changes in chronic stroke patients[J]. Chin J Magn Reson Imaging, 2021, 12(2): 1-5. DOI:10.12015/issn.1674-8034.2021.02.001.

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