Share：
Share this content in WeChat
X
[Chinese][PDF]1359129
• Reviews •
Current status and progression of MRI quantitative research in brown adipose tissue
SHAO Shuying  ZHAO Jian 

Cite this article as: Shao SY, Zhao J. Current status and progression of MRI quantitative research in brown adipose tissue[J]. Chin J Magn Reson Imaging, 2021, 12(6): 121-124. DOI:10.12015/issn.1674-8034.2021.06.026.


[Abstract] With the improvement of people's living standards and changes in lifestyles, the incidence of obesity in adults and children has increased year by year, and obesity and its complications have become the main factors endangering human health. Brown adipose tissue (BAT) makes mitochondrial oxidative phosphorylation and uncoupling through the characteristic high expression of uncoupling protein 1 (UCP1) to convert chemical energy into heat energy. Recent studies have found that BAT is closely related to obesity-related metabolic diseases, which may provide new ideas and ways to treat obesity. At present, MRI quantitative BAT is still in the exploratory stage. Based on the introduction of BAT, the author reviews the MRI detection technology for quantitative analysis of BAT and the clinical application of BAT.
[Keywords] brown adipose tissue；white adipose tissue；magnetic resonance imaging；obesity

SHAO Shuying   ZHAO Jian*  

Department of Radiology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Zhao J, E-mail: zhaojiansohu@126.com

Conflicts of interest   None.

This work was part of Natural Science Foundation of Hebei Province (No. H2020206548).
Received  2020-12-30
Accepted  2021-01-29
DOI: 10.12015/issn.1674-8034.2021.06.026
Cite this article as: Shao SY, Zhao J. Current status and progression of MRI quantitative research in brown adipose tissue[J]. Chin J Magn Reson Imaging, 2021, 12(6): 121-124. DOI:10.12015/issn.1674-8034.2021.06.026.

1
Hu HH. Magnetic resonance of brown adipose tissue: A review of current techniques[J]. Crit Rev Biomed Eng, 2015, 43(2-3): 161-181. DOI: 10.1615/CritRevBiomedEng.2015014377.
2
Aherne W, Hull D. Brown adipose tissue and heat production in the newborn infant[J]. J Pathol Bacteriol, 1966, 91(1): 223-234.
3
Van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men[J]. N Engl J Med, 2009, 360(15): 1500-1508.
4
Leitner BP, Huang S, Brychta RJ, et al. Mapping of human brown adipose tissue in lean and obese young men[J]. Proc Natl Acad Sci U S A, 2017, 114(32): 8649-8654.
5
Chouchani ET, Kazak L, Spiegelman BM. New advances in adaptive thermogenesis: UCP1 and beyond[J]. Cell Metab, 2019, 29(1): 27-37.
6
Ježek P, Jabůrek M, Porter RK. Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)[J]. Biochim Biophys Acta Bioenerg, 2019, 1860(3): 259-269.
7
Szentirmai É, Kapás L. The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses [J]. Sci Rep, 2017, 7(1): 958.
8
Lehnig AC, Stanford KI. Exercise-induced adaptations to white and brown adipose tissue[J]. J Exp Biol, 2018, 221(Suppl 1): 161570. DOI: 10.1242/jeb.161570.
9
Osuna-Prieto FJ, Martinez-Tellez B, Sanchez-Delgado G, et al. Activation of human brown adipose tissue by capsinoids, catechins, ephedrine, and other dietary components: A systematic review[J]. Adv Nutr, 2019, 10(2): 291-302.
10
Law J, Morris DE, Izzi-Engbeaya C, et al. Thermal imaging is a noninvasive alternative to PET/CT for measurement of brown adipose tissue activity in humans[J]. J Nucl Med, 2018, 59(3): 516-522.
11
Crandall JP, Gajwani P, O JH, et al. Repeatability of brown adipose tissue measurements on FDG PET/CT following a simple cooling procedure for BAT activation[J]. PLoS One, 2019, 14(4): e0214765.
12
Holstila M, Pesola M, Saari T, et al. MR signal-fat-fraction analysis and T2* weighted imaging measure BAT reliably on humans without cold exposure[J]. Metabolism, 2017, 70(5): 23-30.
13
Chen YC, Cypess AM, Chen YC, et al. Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging[J]. J Nucl Med, 2013, 54(9): 1584-1587.
14
Franz D, Karampinos DC, Rummeny EJ, et al. Discrimination between brown and white adipose tissue using a 2-point dixon water-fat separation method in simultaneous PET/MRI[J]. J Nucl Med, 2015, 56(11): 1742-1747.
15
Stahl V, Maier F, Freitag MT, et al. In vivo assessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI [J]. J Magn Reson Imaging, 2017, 45(2): 369-380.
16
Hu HH, Yin L, Aggabao PC, et al. Comparison of brown and white adipose tissues in infants and children with chemical-shift-encoded water-fat MRI[J]. J Magn Reson Imaging, 2013, 38(4): 885-896.
17
Hu HH, Hines CD, Smith DL, et al. Variations in T(2)* and fat content of murine brown and white adipose tissues by chemical-shift MRI[J]. Magn Reson Imaging, 2012, 30(3): 323-329.
18
Hu HH, Smith DL, Nayak KS, et al. Identification of brown adipose tissue in mice with fat-water IDEAL-MRI[J]. J Magn Reson Imaging, 2010, 31(5): 1195-1202.
19
Andersson J, Roswall J, Kjellberg E, et al. MRI estimates of brown adipose tissue in children - Associations to adiposity, osteocalcin, and thigh muscle volume[J]. Magn Reson Imaging, 2019, 58(5): 135-142.
20
Lundström E, Strand R, Johansson L, et al. Magnetic resonance imaging cooling-reheating protocol indicates decreased fat fraction via lipid consumption in suspected brown adipose tissue[J]. PLoS One, 2015, 10(4): e0126705.
21
Jones TA, Wayte SC, Reddy NL, et al. Identification of an optimal threshold for detecting human brown adipose tissue using receiver operating characteristic analysis of IDEAL MRI fat fraction maps[J]. Magn Reson Imaging, 2018, 51(9): 61-68.
22
Wu M, Junker D, Branca RT, et al. Magnetic resonance imaging techniques for brown adipose tissue detection[J]. Front Endocrinol (Lausanne), 2020, 11(8): 421.
23
Deng J, Neff LM, Rubert NC, et al. MRI characterization of brown adipose tissue under thermal challenges in normal weight, overweight, and obese young men[J]. J Magn Reson Imaging, 2018, 47(4): 936-947.
24
Hamilton G, Smith DL, Bydder M, et al. MR properties of brown and white adipose tissues[J]. J Magn Reson Imaging, 2011, 34(2): 468-473.
25
Raiko J, Holstila M, Virtanen KA, et al. Brown adipose tissue triglyceride content is associated with decreased insulin sensitivity, independently of age and obesity[J]. Diabetes Obes Metab, 2015, 17(5): 516-519.
26
Koopmans PJ, Yacoub E. Strategies and prospects for cortical depth dependent T2 and T2* weighted BOLD fMRI studies[J]. Neuroimage, 2019, 197(8): 668-676.
27
Panagia M, Chen YC, Chen HH, et al. Functional and anatomical characterization of brown adipose tissue in heart failure with blood oxygen level dependent magnetic resonance[J]. NMR Biomed, 2016, 29(7): 978-984.
28
Muzik O, Diwadkar VA. Regulation of brown adipose tissue activity by interoceptive CNS pathways: The interaction between brain and periphery[J]. Front Neurosci, 2017, 11(11): 640.
29
Jung CS, Heine M, Freund B, et al. Quantitative activity measurements of brown adipose tissue at 7 T magnetic resonance imaging after application of triglyceride-rich lipoprotein 59Fe-superparamagnetic iron oxide nanoparticle: Intravenous versus intraperitoneal approach[J]. Invest Radiol, 2016, 51(3): 194-202.
30
Yaligar J, Verma SK, Gopalan V, et al. Dynamic contrast-enhanced MRI of brown and beige adipose tissues[J]. Magn Reson Med, 2020, 84(1): 384-395.
31
Deng J, Schoeneman SE, Zhang H, et al. MRI characterization of brown adipose tissue in obese and normal-weight children[J]. Pediatr Radiol, 2015, 45(11): 1682-1689.
32
Riis-Vestergaard MJ, Breining P, Pedersen SB, et al. Evaluation of active brown adipose tissue by the use of hyperpolarized [1-(13)C]pyruvate MRI in mice [J]. Int J Mol Sci, 2018, 19(9): 2597.
33
Branca RT, He T, Zhang L, et al. Detection of brown adipose tissue and thermogenic activity in mice by hyperpolarized xenon MRI[J]. Proc Natl Acad Sci U S A, 2014, 111(50): 18001-18006.
34
Antonacci MA, Mchugh C, Kelley M, et al. Direct detection of brown adipose tissue thermogenesis in UCP1-/- mice by hyperpolarized (129)Xe MR thermometry[J]. Sci Rep, 2019, 9(1): 14865.
35
Branca RT, Zhang L, Warren WS, et al. In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI[J]. PLoS One, 2013, 8(9): e74206.
36
Hui SCN, Ko JKL, Zhang T, et al. Quantification of brown and white adipose tissue based on Gaussian mixture model using water-fat and T2* MRI in adolescents[J]. J Magn Reson Imaging, 2017, 46(3): 758-768.
37
Bai BH, Xie XW, Li DP, et al. Epidemiological studies on osteoporosis in the past five years in China[J]. Chin J Osteopor, 2018, 24(2): 253-258.
38
Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch[J]. Nature, 2008, 454(7207): 961-967.
39
Lee P, Brychta RJ, Collins MT, et al. Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women[J]. Osteoporos Int, 2013, 24(4): 1513-1518.
40
Ponrartana S, Aggabao PC, Hu HH, et al. Brown adipose tissue and its relationship to bone structure in pediatric patients[J]. J Clin Endocrinol Metab, 2012, 97(8): 2693-2698.

PREV Current status and prospect of biparametric and multiparametric magnetic resonance imaging in the evaluation of prostate cancer
NEXT Study of brain magnetic resonance imaging in patients with hypertension and type 2 diabetes mellitus based on DKI technology
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn