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• Clinical Article •
Study on cerebral perfusion changes in patients with Parkinson's disease with different motor subtypes by using arterial spin labeling technique
CHEN Hongri  YANG Wenrui  LI Qingrun  XU Yao  ZHANG Hongying 

Cite this article as: Chen HR, Yang WR, Li QR, et al. Study on cerebral perfusion changes in patients with Parkinson's disease with different motor subtypes by using arterial spin labeling technique[J]. Chin J Magn Reson Imaging, 2021, 12(8): 1-5, 10. DOI:10.12015/issn.1674-8034.2021.08.001.


[Abstract] Objective To analyze the changes of cerebral perfusion in Parkinson's disease (PD) patients with different motor subtypes and their similarities and differences. Materials andMethods Three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) data were collected from 26 patients with tremor dominant (TD) Parkinson's disease, 27 patients with postural instability/gait difficulty (PIGD) and 35 normal controls (NC). SPM based on MATLAB were used to data processing. Covariance analysis and double sample t test were used to detect the differences of local cerebral perfusion among the groups to observe cerebral perfusion changes and their differences in patients with different subtypes of PD. The cognitive function of the patients was evaluated with the MMSE score. Pearson correlation method was used to calculate the correlation between relative cerebral blood flow (rCBF) and clinical scores in different motor subtypes of PD.Results Compared with healthy controls, TD group showed increased perfusion in left parahippocampal gyrus, left fusiform gyrus, left precentral gyrus, left postcentral gyrus, bilateral thalamus, and bilateral cerebellum,while decreased perfusion in right temporal pole (middle and superior temporal gyrus),and right middle frontal gyrus (P＜0.05); compared with healthy controls, PIGD group showed increased perfusion in left hippocampus, left parahippocampal gyrus, left fusiform gyrus, left precentral gyrus, left paracentral lobule and bilateral thalamus,while decreased perfusion in left inferior temporal gyrus, left superior marginal gyrus, and right middle frontal gyrus (P＜0.05); compared with PIGD group, the TD group showed increased perfusion in right cerebellum and the left precentral perfusion was decreased (P＜0.05). Additionally, rCBF values of the left precentral gyrus and right cerebellum 8 region was positively correlated with TD scores in the TD group (r=0.397, 0.541, P＜0.05), and rCBF values was positively correlated with MMSE scores (r=0.411, P=0.04) in the PIGD group.Conclusions The cerebral perfusion patterns of PD patients with different motor subtypes were different, the perfusion changes of TD patients mainly existed in the brain areas associated with cerebello-thalamo-cortical (CTC) circuit, while the PIGD patients mainly existed in the striatal-thalamo-cortical (STC) circuit. The characteristic perfusion patterns of different motor subtypes of PD contribute to the pathophysiological mechanism exploration and the clinical classification diagnosis.
[Keywords] Parkinson's disease；resting tremor；postural instability gait difficulty；magnetic resonance imaging；arterial spin labeling

CHEN Hongri1, 2   YANG Wenrui1, 2   LI Qingrun1, 2   XU Yao2   ZHANG Hongying2*  

1 Dalian Medical University, Dalian 116044, China

2 Department of Imaging, North Jiangsu People's Hospital, Yangzhou 225001, China

Zhang HY, E-mail: zhying11@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was part of National Natural Science Foundation of China (No. 81471642).
Received  2021-01-27
Accepted  2021-05-31
DOI: 10.12015/issn.1674-8034.2021.08.001
Cite this article as: Chen HR, Yang WR, Li QR, et al. Study on cerebral perfusion changes in patients with Parkinson's disease with different motor subtypes by using arterial spin labeling technique[J]. Chin J Magn Reson Imaging, 2021, 12(8): 1-5, 10. DOI:10.12015/issn.1674-8034.2021.08.001.

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