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• Clinical Article •
Study on long-rage and short-rage functional connectivity strength of brain network hubs in patients with subcortical ischemic vascular disease
HUANG Jing  CHENG Runtian  LIU Xiaoshuang  LUO Tianyou 

Cite this article as: Huang J, Cheng RT, Liu XS, et al. Study on long-rage and short-rage functional connectivity strength of brain network hubs in patients with subcortical ischemic vascular disease[J]. Chin J Magn Reson Imaging, 2021, 12(11): 7-11. DOI:10.12015/issn.1674-8034.2021.11.002.


[Abstract] Objective To explore the characteristics of long-rage and short-rage functional connectivity strength (FCS) of brain network hubs in patients with subcortical ischemic vascular disease (SIVD).Materials and Methods: Thirty patients with SIVD and 22 normal controls (NC) were scanned with resting-state functional magnetic resonance imaging. Maps of long-rage, short-rage FCS and brain network hubs were obtained by calculation. The difference of the long-rage and short-rage FCS of brain network hubs between groups were compared and the relationship between difference and cognitive function scores were assessed.Results Brain network hubs were mainly distributed in cuneus lobe, precuneus lobe, lingual gyrus, middle cingulate gyrus, posterior cingulate gyrus, fusiform gyrus and calcarine. Compared with NC group, the long-rage and short-rage FCS values of the bilateral superior temporal gyrus, calcarine and the short-rage FCS values of the right insula decreased, the long-rage and short-rage FCS values of the right superior frontal gyrus and the long-rage FCS values in the right precuneus increased in SIVD group (all P＜0.05). In SIVD group, the long-rage FCS values of the right superior temporal gyrus (r=0.438, P=0.022) and the short-rage FCS values of right insula (r=0.390, P=0.044) were correlated with cognitive function scores.Conclusions There are abnormal long-rage and short-rage FCS changes in some brain network hubs of patients with SIVD, especially in insula and superior temporal gyrus, which may help to reveal its neural mechanism.
[Keywords] subcortical ischemic vascular disease；resting-state functional magnetic resonance imaging；functional connectivity strength；brain network hub

HUANG Jing   CHENG Runtian   LIU Xiaoshuang   LUO Tianyou*  

Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Luo TY, E-mail: ltychy@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81671666).
Received  2021-06-30
Accepted  2021-09-24
DOI: 10.12015/issn.1674-8034.2021.11.002
Cite this article as: Huang J, Cheng RT, Liu XS, et al. Study on long-rage and short-rage functional connectivity strength of brain network hubs in patients with subcortical ischemic vascular disease[J]. Chin J Magn Reson Imaging, 2021, 12(11): 7-11. DOI:10.12015/issn.1674-8034.2021.11.002.

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