Share：
Share this content in WeChat
X
[Chinese][PDF]84588
• Clinical Article •
Study on plaque characteristics of basilar artery with mild and severe curvature based on HR-MRI
ZHANG Dingyue  SUN Jiali  LIU Guoqiang  ZHOU Zhongkai  WANG Wei 

Cite this article as: Zhang DY, Sun JL, Liu GQ, et al. Study on plaque characteristics of basilar artery with mild and severe curvature based on HR-MRI[J]. Chin J Magn Reson Imaging, 2021, 12(11): 12-15, 36. DOI:10.12015/issn.1674-8034.2021.11.003.


[Abstract] Objective To study the differences in the distribution, size and composition of basilar artery (BA) plaques using high resolution magnetic resonance imaging (HR-MRI) among patients with mild and severe BA curvature.Materials and Methods: By three-dimension time of flight magnetic resonance angiography (3D-TOF-MRA), patients with BA curvature were included in the study. The transverse distance from the outer wall of the vessel at the maximum curvature of BA to both ends of BA (the junction line between the top of BA and the confluence of the left and right vertebral arteries) was measured and divided into mild curvature group (5 mm＜transverse distance＜10 mm) and severe curvature group (transverse distance≥10 mm). Clinical factors, plaque distribution (inner arc, outer arc), size (minimal plaque, apparent plaque) and composition [intraplaque hemorrhage (IPH)] were compared between the two groups.Results Ninety-two patients with 106 plaques were enrolled, including 54 patients with 60 BA plaques in the mild BA curvature group and 38 patients with 46 BA plaques in the severe BA curvature group. BA plaques were common in the inner arc between the two groups (inner arc vs. outer arc: 76.7%, 73.9% vs. 23.3%, 26.1%). The plaques were more obvious in the severe BA curvature group than in the mild BA curvature group (severe vs. mild: 65.2% vs. 36.7%), and the difference was statistically significant (P=0.004). The proportion of IPH in the severe BA curvature group was higher than that in the mild BA curvature group (severe vs mild: 69.6% vs. 25.0%), and the difference was statistically significant (P＜0.001). There were no statistically significant differences in clinical related factors between the two groups (P＞0.05).Conclusions The curved basilar atherosclerotic plaques are mostly distributed in the inner arc. Apparent plaques are more likely to occur in the severe BA curvature group than in the mild BA curvature group, and the proportion of IPH in the severe BA curvature group is higher than that in the mild BA curvature group, and the plaque in the mild BA curvature group is more stable.
[Keywords] basilar artery；atherosclerotic；high-resolution；magnetic resonance imaging；plaque

ZHANG Dingyue   SUN Jiali   LIU Guoqiang   ZHOU Zhongkai   WANG Wei*  

Department of Magnetic Resonance, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Wang W, E-mail: 1391082196@qq.com

Conflicts of interest   None.

Received  2021-05-31
Accepted  2021-09-24
DOI: 10.12015/issn.1674-8034.2021.11.003
Cite this article as: Zhang DY, Sun JL, Liu GQ, et al. Study on plaque characteristics of basilar artery with mild and severe curvature based on HR-MRI[J]. Chin J Magn Reson Imaging, 2021, 12(11): 12-15, 36. DOI:10.12015/issn.1674-8034.2021.11.003.

[1]
Xiao J, Padrick MM, Jiang T, et al. Acute ischemic stroke versus transient ischemic attack: differential plaque morphological features in symptomatic intracranial atherosclerotic lesions[J]. Atherosclerosis, 2021, 319: 72-78. DOI: 10.1016/j.atherosclerosis.2021.01.002.
[2]
Zhang JY, Zhang K, Jia BX, et al. Risk of recurrence of symptomatic intracranial atherosclerosis in posterior circulation seen to be higher than that in anterior circulation in long-term follow-up[J]. Front Neurol, 2020, 11: 574926. DOI: 10.3389/fneur.2020.574926.
[3]
Frid P, Drake M, Giese AK, et al. Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study[J]. J Neurol, 2020, 267(3): 649-658. DOI: 10.1007/s00415-019-09613-5.
[4]
Kim BJ, Kim SM, Kang DW, et al. Vascular tortuosity may be related to intracranial artery atherosclerosis[J]. Int J Stroke, 2015, 10(7): 1081-1086. DOI: 10.1111/ijs.12525.
[5]
Kim BJ, Kim HY, Jho W, et al. Asymptomatic basilar artery plaque distribution and vascular geometry[J]. J Atheroscler Thromb, 2019, 26(11): 1007-1014. DOI: 10.5551/jat.47365.
[6]
Sun J, Liu G, Zhang D, et al. The longitudinal distribution and stability of curved basilar artery plaque: a study based on HR-MRI[J]. J Atheroscler Thromb, 2021. [ DOI: ]. DOI: 10.5551/jat.62448.
[7]
Shi Z, Zhu CC, Degnan AJ, et al. Identification of high-risk plaque features in intracranial atherosclerosis: initial experience using a radiomic approach[J], 2018, 28(9): 3912-3921. DOI: 10.1007/s00330-018-5395-1.
[8]
Thijs V, Grittner U, Fazekas F, et al. Dolichoectasia and small vessel disease in young patients with transient ischemic attack and stroke[J]. Stroke, 2017, 48(9): 2361-2367. DOI: 10.1161/strokeaha.117.017406.
[9]
Xu WH, Li ML, Gao S, et al. In vivo high-resolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis[J]. Atherosclerosis, 2010, 212(2): 507-511. DOI: 10.1016/j.atherosclerosis.2010.06.035.
[10]
Zhou L, Yan YF, Du H, et al. Plaque features and vascular geometry in basilar artery atherosclerosis[J]. Medicine (Baltimore), 2020, 99(18): e19742. DOI: 10.1097/md.0000000000019742.
[11]
Guo RC, Zhang XB, Zhu XJ. Morphologic characteristics of severe basilar artery atherosclerotic stenosis on 3D high-resolution MRI[J], 2018, 18(1): 206. DOI: 10.1186/s12883-018-1214-1.
[12]
Almallouhi E, Al Kasab S, Yamada L, et al. Relationship between vascular risk factors and location of intracranial atherosclerosis in the SAMMPRIS Trial[J]. J Stroke Cerebrovasc Dis, 2020, 29(5): 104713. DOI: 10.1016/j.jstrokecerebrovasdis.2020.104713.
[13]
Fu X, Li XL, Xiong L, et al. Cerebral arterial stiffness as a new marker of early stage atherosclerosis of the cerebral large artery in acute stroke[J]. J Atheroscler Thromb, 2019, 26(9): 783-791. DOI: 10.5551/jat.46573.
[14]
Nishikata M, Hirashima Y, Tomita T, et al. Measurement of basilar artery bending and elongation by magnetic resonance cerebral angiography: relationship to age, sex and vertebral artery dominance[J]. Arch Gerontol Geriatr, 2004, 38: 251-259. DOI: 10.1016/j.archger.2003.10.006.
[15]
Chakraborty S, Njah K, Pobbati AV, et al. Agrin as a mechanotransduction signal regulating yap through the hippo pathway[J]. Cell Rep, 2017, 18(10): 2464-2479. DOI: 10.1016/j.celrep.2017.02.041.
[16]
Myasoedova VA, Kirichenko TV, Melnichenko AA, et al. Anti-atherosclerotic effects of a phytoestrogen-rich herbal preparation in postmenopausal women[J]. Int J Mol Sci, 2016, 17(8): 1318. DOI: 10.3390/ijms17081318.
[17]
Souilhol C, Serbanovic-Canic J, Fragiadaki M, et al. Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes[J], 2020, 17(1): 52-63. DOI: 10.1038/s41569-019-0239-5.
[18]
Yang WJ, Wong KS, Chen XY. Intracranial atherosclerosis: from microscopy to high-resolution magnetic resonance imaging[J]. J Stroke, 2017, 19(3): 249-260. DOI: 10.5853/jos.2016.01956.
[19]
Montanino A, Fortunato A, Angelillo M. A new simplified methodology for studying the coupled fluid-structure interaction in a weakened basilar artery[J]. Int J Numer Method Biomed Eng, 2016, 32(7): 2752. DOI: 10.1002/cnm.2752.
[20]
Schindler A, Schinner R, Altaf N, et al. Prediction of stroke risk by detection of hemorrhage in carotid plaques: Meta-analysis of individual patient data[J]. JACC Cardiovasc Imaging, 2020, 13: 395-406. DOI: 10.1016/j.jcmg.2019.03.028.
[21]
Sun J, Underhill HR, Hippe DS, et al. Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage: a long-term time course study[J]. JACC Cardiovasc Imaging, 2012, 5(8): 798-804. DOI: 10.1016/j.jcmg.2012.03.014.
[22]
Lin YX, Li JK. Comparison of intravoxel incoherent motion diffusion-weighted MR imaging and arterial spin labeling MR imaging in gliomas[J]. 2015, 2015: 234245. DOI: 10.1155/2015/234245.

PREV Study on long-rage and short-rage functional connectivity strength of brain network hubs in patients with subcortical ischemic vascular disease
NEXT Preliminary study of quantitative susceptibility mapping in the brain iron deposition of unilateral middle cerebral artery stenosis or occlusion
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn