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Research progress of cerebellar structure and functional magnetic resonance imaging in Parkinson's disease
CHENG Xiu  ZHANG Pengfei  WANG Jun  WANG Jin  LI Jiachen  LI Jie  ZHANG Jing 

Cite this article as: Cheng X, Zhang PF, Wang J, et al. Research progress of cerebellar structure and functional magnetic resonance imaging in Parkinson's disease[J]. Chin J Magn Reson Imaging, 2022, 13(4): 146-149. DOI:10.12015/issn.1674-8034.2022.04.032.


[Abstract] Parkinson's disease (PD) is the second largest neurodegenerative disease after Alzheimer's disease. It is considered a "classic" basal ganglia disease, so most research on PD has focused on the basal ganglia, while the cerebellum is often overlooked. In recent years, more and more anatomical, pathophysiological and clinical evidences have shown that the cerebellum plays a very important role in the occurrence and development of PD. With the rapid development of MRI technology, more and more scholars have found that there are obvious changes in the cerebellar structure and functional MRI of PD patients, and these changes are related to movement, cognition, sleep function, etc. This paper summarizes the changes of cerebellar structure and functional MRI in PD patients. The results show that there are obvious gray matter atrophy, white matter microstructure changes, abnormalities in spontaneous neuronal activity and changes in perfusion patterns, etc. in the cerebellum of PD patients. However, so far, studies on the structural and functional MRI changes of the cerebellum in PD patients have shown great heterogeneity, and there is no PD-specific atrophy pattern or related specific imaging indicators. In the future, it is expected to search for sensitive neuroimaging biomarkers for early diagnosis of PD from the perspective of the cerebellum.
[Keywords] Parkinson's disease；pathological mechanism；cerebellum；magnetic resonance imaging；resting-state functional magnetic resonance imaging；diffusion tensor imaging；brain structure；brain function

CHENG Xiu1, 2   ZHANG Pengfei1, 2   WANG Jun1, 2   WANG Jin1, 2   LI Jiachen1, 2   LI Jie1, 2   ZHANG Jing1*  

1 Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China

2 The Second Clinical Medicine College of Lanzhou University, Lanzhou 730030, China

Zhang J, E-mail: lztong2001@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81960309); Lanzhou University Second Hospital "Cuiying Technology" Project (No. CY2018-QN03); Lanzhou University Second Hospital "Cuiying Technology Innovation" Program (No. CY2018-MS02).
Received  2021-10-20
Accepted  2022-04-01
DOI: 10.12015/issn.1674-8034.2022.04.032
Cite this article as: Cheng X, Zhang PF, Wang J, et al. Research progress of cerebellar structure and functional magnetic resonance imaging in Parkinson's disease[J]. Chin J Magn Reson Imaging, 2022, 13(4): 146-149. DOI:10.12015/issn.1674-8034.2022.04.032.

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