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• Clinical Article •
The value of MAP-MRI and DCE-MRI in differentiating glioblastoma from brain metastases
HAO Zhiyue  GAO Yang  Wu Qiong  Wang Shaoyu  Zhang Huapeng 

Cite this article as: HAO Z Y, GAO Y, Wu Q, et al. The value of MAP-MRI and DCE-MRI in differentiating glioblastoma from brain metastases[J]. Chin J Magn Reson Imaging, 2023, 14(2): 12-20. DOI:10.12015/issn.1674-8034.2023.02.003.


[Abstract] Objective To explore the clinical value of mean apparent propagator MRI (MAP-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) in differentiating glioblastoma (GBM) from brain metastases (BMs).Materials and Methods Twenty-seven patients with GBM [isocitrate dehydrogenase-wildtype (IDH-wt)] who were confirmed by surgery and twenty-four patients with BMs confirmed by surgery or clinical follow-up performed conventional MRI sequences, diffusion spectrum imaging (DSI) and DCE-MRI. The parameters of MAP-MRI were obtained by DSI analysis. And the parameters of DCE are processed by Siemens workstation. The parameters of the tumor parenchyma area and peritumoral edema area and the contralateral normal brain tissue in these two groups were measured on each parameter map. To minimize individual differences, the values of each parameter were divided by the values of the contralateral normal brain tissue to obtain the relative values of each parameter. χ2 test was used to compare the gender of the two groups; independent samples t-test and Mann-Whitney U-test were used to compare the parameters and relative parameters of MAP-MRI and DCE-MRI between the two groups. P＜0.05 was considered to be significant. Then analysis was performed. The DeLong test was used to evaluate the differential diagnosis efficiency of each parameter.Results There was no significant difference in age and sex between the two groups (P=0.327 and P=0.247). In the GBM (IDH-wt) group, the non Gaussian axial (NGAx), non Gaussian vertical (NGRad), return to the axis probability (RTAP) and return to the plane probability (RTPP) were higher than those of BMs group, and mean square displacement (MSD) was lower than that in BMs group, and the difference was significant (P＜0.05). The relative volume transfer constant (rKtrans) of peritumoral edema area in GBM (IDH-wt) group was higher than that in BMs, while the relative rate constant (rKep) was lower than that in BMs group, and the difference was significant (P＜0.05). RTPP and NGAx of tumor parenchyma area are the parameters with higher AUC for differentiating GBM (IDH-wt) group BMs. The AUC is 0.985 and 0.937, and the sensitivity is 0.963 and 0.926, and the specificity is 0.917 and 0.833, respectively.Conclusions MAP-MRI and DCE-MRI showed great diagnostic value in differentiating GBM (IDH-wt) from BMs. RTPP and NGAx in tumor parenchymal area could be used as good imaging markers.
[Keywords] glioblastoma；brain metastasis；magnetic resonance imaging；dynamic contrast enhanced；mean apparent propagator-magnetic resonance imaging；antidiastole

HAO Zhiyue1   GAO Yang1*   Wu Qiong1   Wang Shaoyu2   Zhang Huapeng2  

1 Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

2 Siemens Medical System Co., Ltd., Shanghai 201318, China

*Correspondence to: Gao Y, E-mail: 1390903990@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Inner Mongolia Autonomous Region Science and Technology Plan Project (No. 2019GG047).
Received  2022-08-15
Accepted  2023-02-01
DOI: 10.12015/issn.1674-8034.2023.02.003
Cite this article as: HAO Z Y, GAO Y, Wu Q, et al. The value of MAP-MRI and DCE-MRI in differentiating glioblastoma from brain metastases[J]. Chin J Magn Reson Imaging, 2023, 14(2): 12-20. DOI:10.12015/issn.1674-8034.2023.02.003.

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