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• Clinical Article •
Resting-state fMRI study on altered spontaneous brain activity of Parkinson's disease patients with and without rapid eye movement sleep behavior disorder
XIN Ziyue  ZHOU Qichen  QI Yapeng  WANG Yihan  LIU Jianren  ZHANG Kaihua  CHEN Wei  DU Xiaoxia 

Cite this article as: XIN Z Y, ZHOU Q C, QI Y P, et al. Resting-state fMRI study on altered spontaneous brain activity of Parkinson's disease patients with and without rapid eye movement sleep behavior disorder[J]. Chin J Magn Reson Imaging, 2024, 15(4): 1-8. DOI:10.12015/issn.1674-8034.2024.04.001.


[Abstract] Objective Rapid eye movement sleep behavior disorder (RBD) is a common non-motor symptom of Parkinson's disease (PD) and an important prognostic factor. This study analyzed the degree centrality (DC) and amplitude of low-frequency fluctuation (ALFF) values among three groups of PD patients with and without RBD, as well as the healthy control group, using resting-state functional magnetic resonance imaging to explore the brain functional activity characteristics and RBD-specific brain regions of PD patients with RBD (PD-RBD), and to explore the pathological mechanism of RBD occurrence.Materials and Methods The study analyzed data from 20 PD patients with RBD (PD-RBD group), 40 PD patients without RBD (PD-nonRBD group), and 44 healthy controls (HC group), three groups of participants underwent magnetic resonance scanning. DC and ALFF values were calculated to measure brain activity.Results The results showed that the brain regions most affected by DC values were the right anterior central gyrus, superior temporal gyrus, cerebellum, and middle frontal gyrus (P<0.05, FDR-corrected). The left parahippocampal gyrus, cuneiform lobe, and lingual gyrus were the main regions affected by ALFF values (P<0.05, FDR-corrected). Further analysis revealed that PD-RBD patients had an increased DC value in the right middle frontal gyrus compared to PD-nonRBD patients (t=4.02, P=0.007, FDR-corrected), while the DC value of the left precuneus decreased (t=5.30, P=0.009, FDR-corrected). Compared to the control group, PD-RBD patients had increased DC values in the left superior frontal gyrus, cerebellum, right superior temporal gyrus, left middle temporal gyrus, and middle frontal gyrus (P<0.05, FDR-corrected), while the DC values of the left anterior central gyrus, superior temporal gyrus, and middle temporal gyrus were decreased (P<0.05, FDR-corrected). The ALFF value of the right cuneus was also reduced (P<0.05, FDR-corrected).Conclusions These findings suggest that PD-RBD patients have unique imaging features on DC and ALFF, especially, functional abnormalities in the right middle frontal gyrus and left anterior cuneiform lobe may be closely related to the occurrence of RBD in PD patients.
[Keywords] Parkinson's disease；rapid eye movement sleep behavior disorder；resting-state functional magnetic resonance imaging；magnetic resonance imaging；amplitudes of low-frequency fluctuation；degree centrality

XIN Ziyue1   ZHOU Qichen1   QI Yapeng1   WANG Yihan1   LIU Jianren2   ZHANG Kaihua3   CHEN Wei2*   DU Xiaoxia1*  

1 School of Psychology, Shanghai University of Sport, Sports and Brain Research Center, Shanghai 200438, China

2 Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

3 College of Psychology, Shandong Normal University, Jinan 250014, China

Corresponding author: CHEN W, E-mail: david_chen8106@hotmail.com DU X X, E-mail: duxiaoxia@sus.edu.cn

Conflicts of interest   None.

Received  2023-10-11
Accepted  2024-03-25
DOI: 10.12015/issn.1674-8034.2024.04.001
Cite this article as: XIN Z Y, ZHOU Q C, QI Y P, et al. Resting-state fMRI study on altered spontaneous brain activity of Parkinson's disease patients with and without rapid eye movement sleep behavior disorder[J]. Chin J Magn Reson Imaging, 2024, 15(4): 1-8. DOI:10.12015/issn.1674-8034.2024.04.001.

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