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• Clinical Article •
Study of cerebral microstructure in patients with cerebral small vessel disease on intravoxel incoherent motion
GAO Xiang  PENG Ruchen 

Cite this article as: Gao X, Peng RC. Study of cerebral microstructure in patients with cerebral small vessel disease on intravoxel incoherent motion. Chin J Magn Reson Imaging, 2019, 10(9): 641-644. DOI:10.12015/issn.1674-8034.2019.09.001.


[Abstract] Objective: To investigate the feasibility of intravoxel incoherent motion (IVIM) in cerebral small vessel disease by studying microvasculature and parenchyma.Materials and Methods: Sixty-six patients with cerebral small vessel disease and thirty controls were retrospectively studied. IVIM images were used to measure the perfusion volume fraction f and parenchymal diffusivity D of the normal appearing white matter, deep grey matter, cortex and white matter hyperintensity. Group differences of them were investigated.Results: There were significant differences in the perfusion volume fraction f between two groups in the normal appearing white matter (t=2.548, P=0.011), deep grey matter (t=1.988, P<0.001) and cortex (t=2.731, P=0.023). The perfusion volume fraction f (×10-2) of patients (normal appearing white matter 2.32±0.03, deep grey matter 2.94±0.04 and cortex 2.53±0.04) is higher than that of controls (normal appearing white matter 2.21±0.03, deep grey matter 2.68±0.05 and cortex 2.41±0.04). There were significant differences in the parenchymal diffusivity D between two groups in the normal appearing white matter (t=2.003, P=0.002), deep grey matter (t=2.186, P=0.003), cortex (t=2.569, P=0.012) and white matter hyperintensity (t=2.926, P=0.031). The parenchymal diffusivity D (×10-4) of patients (normal appearing white matter 7.34±0.04, deep grey matter 7.76±0.05, cortex 7.42±0.03 and white matter hyperintensity 9.37±0.10) is higher than that of controls (normal appearing white matter 7.16±0.04, deep grey matter 7.55±0.05, cortex 7.31±0.04 and white matter hyperintensity 8.94±0.12).Conclusions: The perfusion volume fraction f and parenchymal diffusivity D of the normal appearing white matter, deep grey matter and cortex in patients with cerebral small vessel disease are significantly higher than those in controls. IVIM can show anomalies in the perfusion volume fraction f and parenchymal diffusivity D. This suggests that IVIM imaging can help to detect and monitor the progression of cerebral small vessel disease.
[Keywords] cerebral small vessel diseases；magnetic resonance imaging

GAO Xiang Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China

PENG Ruchen* Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China

*Correspondence to: Peng RC, E-mail: 13501271260@163.com

Conflicts of interest   None.

Received  2019-02-15
Accepted  2019-06-07
DOI: 10.12015/issn.1674-8034.2019.09.001
Cite this article as: Gao X, Peng RC. Study of cerebral microstructure in patients with cerebral small vessel disease on intravoxel incoherent motion. Chin J Magn Reson Imaging, 2019, 10(9): 641-644. DOI:10.12015/issn.1674-8034.2019.09.001.

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