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• Clinical Article •
Investigating the changes of ALFF of hearing related cortex of infants with sensorineural hearing loss by using fMRI
LIU Mengqiu  LIU Jie  LIU Ying 

Cite this article as: Liu MQ, Liu J, Liu Y. Investigating the changes of ALFF of hearing related cortex of infants with sensorineural hearing loss by using fMRI. Chin J Magn Reson Imaging, 2019, 10(9): 650-654. DOI:10.12015/issn.1674-8034.2019.09.003.


[Abstract] Objective: To study the changes of low frequency amplitude (ALFF) in hearing related brain regions of children with bilateral congenital severe sensorineural deafness (BCSSD) using resting-state functional magnetic resonance imaging (rs-fMRI).Materials and Methods: Twenty-five children (0-4 years old) with BCSSD were recruited in this study and they were divided into two groups: 16 "younger" children with ages below 2 years old and 9 "older" children with ages above 2 years old. Twenty age-matched healthy children (9 in the "younger" group and 11 in the "older" group) were also recruited as controls. All rs-fMRI scans were performed on a 3.0 T GE scanner (discovery 750 w). Data were analyzed to produce ALFF values in different brain regions.Results: In the "younger" group, patients with BCSSD had higher ALFF values compared to healthy controls in left anterior cuneiform lobe, right superior frontal gyrus, right middle occipital gyrus and right parietal lobule. Patients also showed lower ALFF values in left superior temporal gyrus and left inferior frontal gyrus. In the "older" group, patients with BCSSD had higher ALFF values in left anterior cingulate gyrus and left infratemporal gyrus. On the contrary, lower ALFF values were found in left inferior frontal gyrus and left superior temporal gyrus in patients, compared to healthy controls. Comparisons were also performed within the patient group, our results showed that "younger" patients had higher ALFF values in left superior temporal gyrus, left inferior frontal gyrus and insula, and had lower ALFF values in right medial frontal gyrus and left inferior temporal gyrus, compared to "older" patients.Conclusions: The results in this study indicate that functional remodeling may occur in the auditory sensory cortex of children with BCSSD. Functional magnetic resonance imaging can be used as a potential tool to assist preoperative evaluation and prognosis judgement of cochlear implants.
[Keywords] resting state；low frequency amplitude；congenital sensorineural deafness；magnetic resonance imaging

LIU Mengqiu Department of Radiology, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China

LIU Jie Department of Radiology, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China

LIU Ying* Department of Radiology, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China

*Correspondence to: Liu Y, E-mail: felice828@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the Anhui Province Public Welfare Technology Application Research Linkage Project Fund of 2017 No. 1704f0804003
Received  2019-02-27
Accepted  2019-06-23
DOI: 10.12015/issn.1674-8034.2019.09.003
Cite this article as: Liu MQ, Liu J, Liu Y. Investigating the changes of ALFF of hearing related cortex of infants with sensorineural hearing loss by using fMRI. Chin J Magn Reson Imaging, 2019, 10(9): 650-654. DOI:10.12015/issn.1674-8034.2019.09.003.

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