Share：
Share this content in WeChat
X
[Chinese][PDF]91574
• Clinical Article •
Cardiac magnetic resonance imaging in obstructive sleep apnea-hypopnea syndrome patients
YUAN Yue  BAO Haihua 

Cite this article as: Yuan Y, Bao HH. Cardiac magnetic resonance imaging in obstructive sleep apnea-hypopnea syndrome patients. Chin J Magn Reson Imaging, 2020, 11(4): 286-290. DOI:10.12015/issn.1674-8034.2020.04.009.


[Abstract] Objective: To investigate the changes of left ventricular function and myocardium in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), and carry out quantitative analysis of myocardial tissue by cardiac magnetic resonance imaging.Materials and Methods: Twenty-four male patients, aged 40—60 years old, and 25 normal adult male healthy volunteers, aged 40—60 years old, who met the 2011 revised OSAHS diagnostic criteria and were diagnosed as OSAHS after polysomnography (PSG) monitoring were selected. Perform the following sequence scans: Multi-temporal cine sequence based on gradient echo, modified look-locker inversion recovery (MOLLI) sequence contrast agent T1 mapping before injection, T2 mapping based on steady-state free-precession (SSFP), T1 scout sequence and MOLLI sequence contrast agent T1 mapping after injection. Left ventricular functional parameters [left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV), end systolic volume (LVESV), stroke volume (LVSV), cardiac output (LVCO), cardiac index (LVCI), left ventricular myocardial mass (LVM)], left ventricular myocardial T1 value, T2 value and ECV value were obtained.Results: (1) Cardiac function related parameters: LVEF, LVEDV, LVSV in OSAHS group were lower than those in normal, LVESV and LVM were higher than that in normal, and the difference was statistically significant (P<0.05); there was no significant difference in ESV, SV and CO between OSAHS and normal (P>0.05). (2) Histological parameters: T2 value of middle segment, apex segment and mean of left ventricular myocardium in OSAHS were higher than those in normal, the difference was statistically significant (P<0.05); the mean pre-contrast T1 and ECV values of left ventricle myocardium in OSAHS were higher than those in normal, but the difference was not statistically significant (P>0.05).Conclusions: (1) Cardiac magnetic resonance imaging technology can effectively evaluate the cardiac structure, function and the early changes of myocardium of OSAHS patients, which has an important clinical application value; (2) Left ventricular systolic and diastolic functions of OSAHS were both reduced differently degrees and myocardial quality was increased; (3) Acute inflammatory changes of different degrees in left ventricular myocardium of OSAHS occur.
[Keywords] obstructive sleep apnea-hypopnea syndrome；cardiac magnetic resonance；cardiac function；myocardial damage；magnetic resonance imaging

YUAN Yue Affiliated Hospital of Qinghai University, Xining 800001, China

BAO Haihua* Affiliated Hospital of Qinghai University, Xining 800001, China

*Correspondence to: Bao HH, E-mail: Baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Science and Technology Program of Qinghai Science and Technology Department No. 2017-SF-158
Received  2019-10-29
Accepted  2019-12-31
DOI: 10.12015/issn.1674-8034.2020.04.009
Cite this article as: Yuan Y, Bao HH. Cardiac magnetic resonance imaging in obstructive sleep apnea-hypopnea syndrome patients. Chin J Magn Reson Imaging, 2020, 11(4): 286-290. DOI:10.12015/issn.1674-8034.2020.04.009.

[1]
中华医学会呼吸病学分会睡眠呼吸疾病学组．阻塞性睡眠呼吸暂停低通气综合征诊治指南（草案)．中华结核和呼吸杂志, 2002, 25(4): 3-6.
[2]
董汉奎，刘茜，孙禾，等．阻塞性睡眠呼吸暂停低通气综合征3例诊治及文献复习.临床肺科杂志, 2007, 12(3): 267-269.
[3]
Guan W, Ga Q, Li R, et al. Sleep disturbances in long-term immigrants with chronic mountain sickness: A comparison with healthy immigrants at high altitude. Respir Physiol Neurobiol, 2015, 206: 4-10.
[4]
潘德锋，刘杰，吴皖灵，等．单纯OSAHS患者心脏结构功能改变及相关危险因子的临床分析.南通大学学报（医学版）, 2018, 38(6): 439-441.
[5]
李春敏，石珊，祝希敏．阻塞性睡眠呼吸暂停低通气综合征患者心脏结构及其舒张功能的研究．医学影像学杂志, 2009, 19(10): 1262-1264.
[6]
Manuel Sánchez-de-la-Torre, Campos-Rodriguez F, Ferran Barbé. Obstructive sleep apnoea and cardiovascular disease. Lancet Respiratory Med, 2013, 1(1): 61-72.
[7]
Jordan AS, Mcsharry DG, Malhotra A. Adult obstructive sleep apnoea. The Lancet, 2014, 383(9918): 736-747.
[8]
Malhotra A, Huang Y, Fogel R, et al. The male predisposition to pharyngeal collapse: the importance of airway length. Am J Respir Crit Care Med, 2002, 166: 1388-1395.
[9]
Yaggi HK, Concato J, Kernan WN, et al. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med, 2005, 353: 2034-2041.
[10]
John P, Melpomeni N, Demosthenes M, et al. Diastolic dysfunction in men with severe obstructive sleep apnea syndrome but without cardiovascular or oxidative stress-related comorbidities. Ther Adv Respir Dis, 2019 DOI: ; 13: DOI: . DOI: 10.1177/1753466619880076.
[11]
赵世华．迎接心脏磁共振成像新技术挑战．中国医学影像技术, 2017, 33(8): 1125-1128.
[12]
凌梦军，陈明．阻塞性睡眠呼吸暂停低通气综合征与高血压关系的研究进展．心血管病学进展, 2019(5): 722-725.
[13]
Messroghli DR, Radjenovic A, Kozerke S, et al. Modified look-locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med, 2004, 52(1): 141-146.
[14]
Messroghli DR, Walters K, Plein S, et al. Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction. Magn Reson Med, 2007, 58(1): 34-40.
[15]
Nakamori S, Dohi K, Ishida M, et al. Native T1 mapping and extracellular volume mapping for the assessment of diffuse myocardial fibrosis in dilated cardiomyopathy. JACC Cardiovasc Imaging, 2018, 11(1): 48-59.
[16]
Kellman P, Wilson JR, Xue H, et al. Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience. J Cardiovasc Magn Reson, 2012, 14: 64.
[17]
Salerno M, Kramer CM. Advances in parametric mapping with CMR imaging. JACC Cardiovasc Imaging, 2013, 6(7): 806-822.
[18]
Bohnen S, Radunski UK, Lund GK, et al. Performance of T1 and T2 mapping cardiovascular magnetic resonance to detect active myocarditis in patients with recent-onset heart failure. Circ Cardiovasc Imaging, 2015, 8(6): e003073.
[19]
He T, Smith GC, Gatehouse PD, et al. On using T2 to assess extrinsic magnetic field inhomogeneity effects on T2* measurements in myocardial siderosis in thalassemia. Magn Reson Med, 2009, 61(3): 501-506.
[20]
Mavrogeni S, Bratis K, Markussis V, et al. The diagnostic role of cardiac magnetic resonance imaging in detecting myocardial inflammation in systemic lupus erythematosus. Differentiation from viral myocarditis. Lupus, 2013, 22(1): 34-43.
[21]
Lavie L, Vishnevsky A, Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep, 2004, 27(1): 123-128.

PREV Cardiovascular magnetic resonance feature tracking in the quantitative assessment of early left atrial dysfunction in hypertensive patients
NEXT Research on IVIM-DWI technique in endocrine treatment effect of prostate cancer
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn