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• Clinical Article •
Research on IVIM-DWI technique in endocrine treatment effect of prostate cancer
SHAN Chunhui  BAO Yunfeng  ZHAO Mingjuan  GUO Liuxiong  HUANG Xiaoying  CHEN Yingmin 

Cite this article as: Shan CH, Bao YF, Zhao MJ, et al. Research on IVIM-DWI technique in endocrine treatment effect of prostate cancer. Chin J Magn Reson Imaging, 2020, 11(4): 291-295. DOI:10.12015/issn.1674-8034.2020.04.010.


[Abstract] Objective: To explore the value of IVIM-DWI technique in the endocrine therapy of prostate cancer (PCa).Materials and Methods: From November 2017 to January 2019, 49 patients with PCa confirmed by pathology after ultrasound-guided rectal puncture in our hospital were collected, and the patients were selected to adopt a uniform drug endocrine therapy regimen. Before the treatment, 3.0 T conventional MRI plain scan plus enhancement and IVIM-DWI sequence scans with 11 b values (0—3000 s/mm2) were performed to measure the apparent diffusion coefficient (ADCstand), slow apparent diffusion coefficient (ADCslow), fast apparent diffusion coefficient (ADCfast), proportion of fast diffusion (Ffast), distributed diffusion coefficient (DDC), and diffusion heterogeneity index (α). Review of MRI after 6 months treatment, and the patients were divided into effective group (31 cases) and ineffective group (18 cases) according to the treatment effect. Independent sample rank sum test was used to compare the differences of the parameters before treatment between the two groups. And the receiver operating characteristic (ROC) was used to evaluate statistically significant parameters for predicting power, with P<0.05 as the statistical standard.Results: ADCfast in the effective group was greater than that in the ineffective group (P<0.05), and Ffast in the effective group was less than that in the ineffective group (P<0.05). The remaining parameters were not significantly different between the two groups. The area under the ROC curve of ADCfast (AUC) was the largest (0.900), followed by Ffast (0.878). Both had the same sensitivity (96.8%), and the specificity of ADCfast was the highest (83.8%).Conclusions: The double-exponential model ADCfast and Ffast of IVIM-DWI technique before treatment can effectively predict the effect of PCa endocrine therapy, and it can provide a basis for individualized treatment of PCa.
[Keywords] prostatic neoplasms；intravoxel incoherent motion；apparent diffiusion coefficent；magnetic resonance imaging

SHAN Chunhui Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

BAO Yunfeng* Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

ZHAO Mingjuan Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

GUO Liuxiong Department of Urology, Hebei General Hospital, Shijiazhuang 050051, China

HUANG Xiaoying Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

CHEN Yingmin Department of Medical Imaging, Hebei General Hospital, Shijiazhuang 050051, China

*Correspondence to: Bao YF, E-mail: byf816@126.com

Conflicts of interest   None.

Received  2019-10-22
Accepted  2019-12-31
DOI: 10.12015/issn.1674-8034.2020.04.010
Cite this article as: Shan CH, Bao YF, Zhao MJ, et al. Research on IVIM-DWI technique in endocrine treatment effect of prostate cancer. Chin J Magn Reson Imaging, 2020, 11(4): 291-295. DOI:10.12015/issn.1674-8034.2020.04.010.

[1]
Siegel RL, Miller KD, Jemal A. Cancer statistics 2016. CA Cancer J Clin, 2016, 66(1): 7-30.
[2]
顾秀瑛，郑荣寿，张思维，等. 2000-2014年中国肿瘤登记地区前列腺癌发病趋势及年龄变化分析．中华预防医学杂志, 2018, 52(6): 586-592.
[3]
Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology, 1986, 161(2): 401.
[4]
James K, Eisenhauer E, Christian M, et al. Measuring response in solid tumors: Unidimensional versus bidimensional measurement. J Natl Cancer Inst, 1999, 91(6): 523-528.
[5]
中国医促会泌尿健康促进分会，中国研究型医院学会泌尿外科学专业委员会．前列腺癌新型内分泌治疗安全共识．现代泌尿外科杂志, 2018, 23(6): 409-417.
[6]
中国抗癌协会泌尿男生殖系肿瘤专业委员会. 2018版转移性前列腺癌诊治中国专家共识．中华外科杂志, 2018, 56(9): 646-652.
[7]
Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer, 2001, 1: 13445.
[8]
Hara T, Miyazaki H, Lee A, et al. Androgen receptor and invasion in prostate cancer. Cancer Res, 2008, 68(4): 1128-1135.
[9]
Horacio M, Haojie H, Schmidt LJ, et al. Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology, 2001, 142(11): 4795-4805.
[10]
Liu W, Liu XH, Tang W, et al. Histogram analysis of stretched-exponential and monoexponential diffusion-weighted imaging models for distinguishing low and intermediate/high gleason scores in prostate carcinoma. J Magn Reson Imaging, 2018, 48(2): 491-498.
[11]
Zhang YD, Wang Q, Wu CJ, et al. The histogram analysis of diffusion-weighted intravoxel incoherent motion (IVIM) imaging for differentiating the gleason grade of prostate cancer. Eur Radiol, 2015, 25(4): 994-1004.
[12]
Yamada I, Aung W, Himeno Y, et al. Diffusion coefficients in abdominal organs and hepatic lesions: Evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology, 1999, 210(3): 617-623.
[13]
Luciani A, Vignaud A, Cavet M, et al. Liver cirrhosis: Intravoxel incoherent motion MR imaging-pilot study. Radiology, 2008, 249(3): 891.
[14]
Turner R, Le Bihan D, Maier J, et al. Echo-planar imaging of intravoxel incoherent motion. Radiology, 1990, 177(2): 407-414.
[15]
Lee HJ, Rha SY, Chung YE, et al. Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: correlation with histological microvessel density. Magn Reson Med, 2014, 71(4): 1554-1558.
[16]
Sigmund EE, Cho GY, Kim S, et al. Intravoxel incoherent motion imaging of tumor microenvironment in locally advanced breast cancer. Magn Reson Med, 2011, 65(5): 1437-1447.
[17]
Le Bihan D, Ichikawa S, Motosugi U. Diffusion and intravoxel incoherent motion MR imaging-based, virtual elastography: A hypothesis-generating study in the liver. Radiology, 2017, 285(2): 609-619.
[18]
Shin HJ, Yoon H, Kim MJ, et al. Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children. World J Gastroenterol, 2018, 24(27): 3013-3020.
[19]
Federau C, Hagmann P, Maeder P, et al. Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle. PLoS One, 2013, 8(8): e72856.

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