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• Clinical Article •
Resting-state fMRI study of amygdala-whole brain functional connectivity after acute alcohol exposure in healthy young adults
XU Shili  YU Tingting  SONG Zhiyan  CHEN Jun 

Cite this article as: Xu SL, Yu TT, Song ZY, et al. Resting-state fMRI study of amygdala-whole brain functional connectivity after acute alcohol exposure in healthy young adults. Chin J Magn Reson Imaging, 2020, 11(5): 336-342. DOI:10.12015/issn.1674-8034.2020.05.004.


[Abstract] Objective: To investigate the changes of functional connectivity (FC) between amygdala and whole brain regions after acute alcohol exposure in healthy young adults.Materials and Methods: Twenty-eight healthy young volunteers were recruited to evaluate the cognitive function with the Mini-mental State Examination (MMSE), MMSE score≥24. fMRI data were collected before and 0.5 h after drinking, and blood alcohol concentration (BAC) was measured at 0.5h after drinking. DPARSF software was used to preprocess the resting state data, and the bilateral amygdala was used as the seed point to correlate with the time series of all other voxels in the whole brain. (1) The paired sample t test was used to compare the difference between amygdala-whole brain FC before and after drinking. (2) The subjects after drinking were divided into high and low groups according to BAC. The independent sample t test was used to compare the FC difference between the two groups.Results: A total of twenty-three healthy volunteers (12 males and 11 females) were enrolled after screening. As compared with that before drinking, left amygdala-whole brain FC enhanced areas include bilateral occipital lobe, left middle temporal gyrus, left inferior parietal gyrus and left cerebellum, FC decreased in right superior frontal gyrus, right middle temporal gyrus, right hippocampus and parahippocampal gyrus (Puncorr<0.001, voxels> 10). Right amygdala-whole brain FC enhanced areas include left anterior central gyrus, right cuneus, FC decreased in left cerebellum, left hippocampus and parahippocampal gyrus, right basal ganglia, left temporal fusiform gyrus (Puncorr<0.001, voxels>10). As compared with the low BAC group, FC of right amygdala-whole brain decreased in left insular lobe, left superior temporal gyrus, left occipital lobe, right middle frontal gyrus in the high BAC group (Puncorr<0.001, voxels> 10). There was no significant difference region in FC of left amygdala-whole brain between high and low BAC groups.Conclusions: Acute alcohol exposure can cause FC changes between amygdala and multiple brain regions, which provides imaging evidence for some clinical manifestations after acute alcohol consumption; the right amygdala may be more susceptible to alcohol.
[Keywords] alcohol drinking；amygdale；brain；magnetic resonance imaging

XU Shili Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

YU Tingting Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

SONG Zhiyan Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

CHEN Jun* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

*Correspondence to: Chen J, E-mail: whuchenjun@163.com

Conflicts of interest   None.

Received  2019-12-13
Accepted  2020-03-28
DOI: 10.12015/issn.1674-8034.2020.05.004
Cite this article as: Xu SL, Yu TT, Song ZY, et al. Resting-state fMRI study of amygdala-whole brain functional connectivity after acute alcohol exposure in healthy young adults. Chin J Magn Reson Imaging, 2020, 11(5): 336-342. DOI:10.12015/issn.1674-8034.2020.05.004.

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