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• Clinical Article •
Study on brain structure network of patients with delayed encephalopathy after carbon monoxide poisoning: Based on diffusion tensor imaging
JIANG Wenqian  WU Qingyu  ZHAO Ziru  WANG Liang  ZHOU Lu  LI Dan  HE Laichang  TAN Yongming 

Cite this article as: Jiang WQ, Wu QY, Zhao ZR, et al. Study on brain structure network of patients with delayed encephalopathy after carbon monoxide poisoning: Based on diffusion tensor imaging. Chin J Magn Reson Imaging, 2020, 11(12): 1109-1114. DOI:10.12015/issn.1674-8034.2020.12.006.


[Abstract] Objective: Diffusion tensor imaging (DTI) was used to measure the changes in brain structural networks of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) patients, and to explore the neuroimaging mechanism of DEACMP cognitive disorder.Materials and Methods: DTI scans were performed on 25 DEACMP patients and 25 Healthy Controls (HCs) matched by age and gender. The AAL template was used to divide the whole brain into 90 regions. The continuous tracer method was used to reconstruct the brain fiber bundle connection network and the brain structure-weighted network. The global and regional properties were computed by graph theoretical analysis. To compare the brain network regional properties between two groups, two-sample t-test (false discovery rate correction, P<0.05) was utilized. The correlations between the brain structural network properties and clinical parameters were further analysed.Results: Both of the two groups were found to follow the efficient small-world characteristics. The shortest path length of the DEACMP group increased (Lp=0.86±0.05), global efficiency (Eglob=9.60±2.65) and local efficiency (Eloc=17.98±3.89) decreased. Moreover, the core nodes of the DEACMP group's default network, highlighting network, central execution network, and visual area were reduced (P<0.05, FDR correction). The left amygdala node degree of DEACMP group was positively correlated with MMSE and MoCA (r=0.863, P=0.001; r=0.525, P=0.021); the left tongue gyrus degree value was positively correlated with MoCA (r=0.406, P=0.019), and CDR negative correlation (r=-0.563, P=0.016). The efficiency value of the right dorsolateral superior frontal gyrus node in the DEACMP group was negatively correlated with the CDR score (r=-0.377, P=0.031).Conclusions: The difference of topology attributes and nodes in DEACMP patients can show the degree of damage to related brain regions, especially to advanced brain functions, in DEACMP patients.
[Keywords] carbon monoxide poisoning；delayed encephalophthy；diffusion tensor imaging；brain network；small-worldness

JIANG Wenqian Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330000, China

WU Qingyu Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330000, China

ZHAO Ziru Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330000, China

WANG Liang Department of Rehabilitation, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

ZHOU Lu Department of Rehabilitation, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

LI Dan Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330000, China

HE Laichang Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330000, China

TAN Yongming* Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330000, China

*Correspondence to: Tan YM, E-mail: tanyongming1209@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Jiangxi Graduate Innovation Special Fund Project No. YC2018-S109 Health Commission of Jiangxi Science and Technology Plan No. 20191040 Science and Technology Plan Fund of Jiangxi Provincial Department of Health No.20181701
Received  2020-10-19
Accepted  2020-11-13
DOI: 10.12015/issn.1674-8034.2020.12.006
Cite this article as: Jiang WQ, Wu QY, Zhao ZR, et al. Study on brain structure network of patients with delayed encephalopathy after carbon monoxide poisoning: Based on diffusion tensor imaging. Chin J Magn Reson Imaging, 2020, 11(12): 1109-1114. DOI:10.12015/issn.1674-8034.2020.12.006.

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