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• Clinical Article •
The value of 3.0 T MR IVIM and DKI in evaluating benign and malignant breast lesions
ZHANG Qie  CHEN Xue  GU Xiaowen  ZHANG Jibin  QIN Mingming  XU Jianming 

Cite this article as: Zhang Q, Chen X, Gu XW, et al. The value of 3.0 T MR IVIM and DKI in evaluating benign and malignant breast lesions. Chin J Magn Reson Imaging, 2020, 11(12): 1115-1118, 1128. DOI:10.12015/issn.1674-8034.2020.12.007.


[Abstract] Objective: To evaluate the independent and combined diagnostic efficacy of 3.0 T MR intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) for benign and malignant breast lesions.Materials and Methods: Prospective collection of 50 female breast lesions (54 lesions in total) who underwent preoperative multi-parameter MR functional imaging and obtained definite pathological results. The diffusion coefficient (D), pseudo-diffusivity coefficient (D*), perfusion fraction (f) and mean diffusion kurtosis coefficient (MK), mean diffusion coefficient (MD) were obtained by using MITK and DKE software. The statistical differences of each parameter were analyzed and ROC curve was used to evaluate the diagnostic efficacy of the parameters with significant differences.Results: There were statistically significant differences between malignant and benign lesions in parameters of D, f, MK and MD values (P<0.05), while there was no significant difference in D* value (P>0.05). Using pathological results as the gold standard, the AUC of D, f, MK and MD values diagnosis of breast benign and malignant lesions were 0.927, 0.664, 0.944 and 0.876, respectively. Using 0.91×10-3 mm2/s, 14.58%, 0.75 and 1.47×10-3 mm2/s as the cut-off of the four parameters, the sensitivity and specificity of differentiating malignant and benign lesions were (90.91%, 95.24%), (57.58%, 76.19%), (87.88%, 85.71%) and (81.82%, 80.95%), respectively.Conclusions: The MK value in IVIM and DKI parameters has larger AUC, while the D value has high sensitivity and specificity. The AUC and sensitivity of D+MK were the highest in the combined diagnosis. IVIM and DKI have clinical value in the differential diagnosis of breast benign and malignant diseases, and the combined application can improve the diagnostic efficiency.
[Keywords] breast tumor；intravoxel incoherent motion；diffusion kurtosis imaging；magnetic resonance imaging

ZHANG Qie Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

CHEN Xue Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

GU Xiaowen Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

ZHANG Jibin* Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

QIN Mingming Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

XU Jianming Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

*Correspondence to: Zhang JB, E-mail: zjb12042@126.com

Conflicts of interest   None.

Received  2020-06-27
Accepted  2020-11-10
DOI: 10.12015/issn.1674-8034.2020.12.007
Cite this article as: Zhang Q, Chen X, Gu XW, et al. The value of 3.0 T MR IVIM and DKI in evaluating benign and malignant breast lesions. Chin J Magn Reson Imaging, 2020, 11(12): 1115-1118, 1128. DOI:10.12015/issn.1674-8034.2020.12.007.

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