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• Clinical Article •
Clinical research of NODDI technology in deep brain nucleus of Parkinson's disease
HUANG Xiaopan  HAN Hongyu  WANG Min  MA Donghui  LI Peishan  WANG Hong 

Cite this article as: Huang XP, Han HY, Wang M, et al. Clinical research of NODDI technology in deep brain nucleus of Parkinson's disease[J]. Chin J Magn Reson Imaging, 2021, 12(3): 6-9, 19. DOI:10.12015/issn.1674-8034.2021.03.002.


[Abstract] Objective To investigate microstructural changes of gray matter nucleus in people with Parkinson's Disease (PD) by neurite orientation dispersion and density imaging (NODDI). Materials andMethods Thirty-six PD patients and 26 healty volunteers underwent MRI and were divided into the case group and the control group, NODDI images were analyzed and processed. Intracellular volume fraction (Vic) and orientation dispersion index (ODI) from the case group were separately compared with those from the control group, and receiver operating characteristic curve (ROC) evaluated the diagnostic efficiency of different nucleus.Results The Vic values of left substantia nigra (P＜0.001), thalamus (P=0.003), right caudate nucleus head (P=0.002), putamen (P＜0.001), globus pallidus (P＜0.001), substantia nigra (P＜0.001), red nucleus (P＜0.001) and thalamus (P=0.006) in PD patients were significantly different from those in the control group. Compared with the control group, the ODI values of left substantia nigra (P＜0.001), right caudate nucleus head (P=0.038), putamen (P=0.001), globus pallidus (P=0.023) substantia nigra (P＜0.001) and red nucleus (P=0.023) in PD patients showed significantly difference. Meanwhile, the ROC curve showed that area under curve (AUC) of the Vic values for PD's diagnosis were respectively 0.861, 0.788, 0.852, 0.843 in right substantia nigra, red nucleus, globus pallidus and putamen. In addition, the AUC of the combined diagnosis of substantia nigra and globus pallidus, substantia nigra and putamen were separately 0.925,0.921.Conclusion NODDI can qualitatively distinguish between PD patients and healthy volunteers, and quantitatively analyze microstructural changes of deep brain nucleus. And the joint diagnosis of nucleus can obtain higher value, which is helpful for PD's clinical diagnosis.
[Keywords] neurite orientation dispersion and density imaging；nucleus；parkinson's disease；magnetic resonance imaging；substantia nigra striatum

HUANG Xiaopan   HAN Hongyu   WANG Min   MA Donghui   LI Peishan   WANG Hong*  

Department of Radiology, Second Affiliated Hospital of Xinjiang Medical Univer sity, Urumqi 830063, China

Wang H, E-mail: wangh_xj@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Xinjiang Uygur Autonomous Region No. 2019D01C227
Received  2020-10-06
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.03.002
Cite this article as: Huang XP, Han HY, Wang M, et al. Clinical research of NODDI technology in deep brain nucleus of Parkinson's disease[J]. Chin J Magn Reson Imaging, 2021, 12(3): 6-9, 19. DOI:10.12015/issn.1674-8034.2021.03.002.

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