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• Clinical Article •
Preliminary study on comparing the ReHo features of resting-state functional MRI between the treatment-resistant and non-treatment-resistant depression
CHEN Limei  GUO Chunlei  LI Xiaojiao  XU Ke  ZHANG Lei  CAO Jiudong  WANG Zhi  SUN Jifei  GAO Deqiang  HE Jiakai  LIU Jun  FANG Jiliang 

Cite this article as: Chen LM, Guo CL, Li XJ, et al. Preliminary study on comparing the ReHo features of resting-state functional MRI between the treatment-resistant and non-treatment-resistant depression[J]. Chin J Magn Imaging, 2021, 12(3): 10-14. DOI:10.12015/issn.1674-8034.2021.03.003.


[Abstract] Objective To explore the brain function difference between the treatment-resistant depression (TRD) and non-treatment-resistant depression (nTRD), the local consistency ReHo (regional homogeniety) method was used to analyze the resting state functional magnetic resonance imaging data,and then the result of functional brain imaging was correlated with the scores of the clinical symptoms' scales. Materials andMethods The study was recruited with 27 TRD patients, 22 nTRD and 22 healthy controls. All subjects were conducted with the resting state fMRI. The fMRI data was processed by DPARSF 5.0. The clinical symptoms were also collected and evaluated with the scales of Depression, Anxiety, and Rumination Response. The one way ANOVA (analysis of variance) was used to test the differences in ReHo among the three groups. The ReHo values of brain areas were correlated with the clinical scales' scores.Results There was no significant difference in demographic data and clinical symptom scores between the two groups of depression patients. However, significant differences in ReHo values were found in the left superior temporal gyrus and multiple brain areas on the right cerebrum. Compared with the nTRD group, the TRD group showed higher ReHo values in the left superior temporal gyrus and the right posterior cerebellum, and lower in the right orbitofrontal gyrus. The ReHo values of the right upper /middle frontal gyrus and orbital frontal gyrus in the TRD group were positively correlated with the RRS scale scores, respectively (P=0.015, r=0.46), (P=0.018, r=0.44).Conclusions Even though there are the similar scale scores of the symptoms between the TRD and non-TRD, an apparent difference exists of brain function ReHo value. Therefore, the physiopathology of TRD involves more brain regions, including emotion, cognition, primary sensory center, etc., which are significantly related to clinical symptoms.
[Keywords] treatment-resistant depression；resting state functional magnetic resonance imaging；brain function；regional homogeneity；rumination response scale

CHEN Limei1   GUO Chunlei1   LI Xiaojiao1   XU Ke1   ZHANG Lei1   CAO Jiudong1   WANG Zhi1   SUN Jifei1   GAO Deqiang1   HE Jiakai2   LIU Jun3*   FANG Jiliang1*  

1 Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

2 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

3 The Second Xiangya Hospital of Central South University, Changsha 410008, China

Fang JL, E-mail: fangmgh@163.com Liu J, E-mail: 2322349829@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 81774433 The National Key Research and Development Program of China No. 2018YFC1705802
Received  2020-11-26
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.03.003
Cite this article as: Chen LM, Guo CL, Li XJ, et al. Preliminary study on comparing the ReHo features of resting-state functional MRI between the treatment-resistant and non-treatment-resistant depression[J]. Chin J Magn Imaging, 2021, 12(3): 10-14. DOI:10.12015/issn.1674-8034.2021.03.003.

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