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• Clinical Article •
DTI quantitative evaluation of brain microstructural changes after melodic intonation therapy in the treatment of Broca aphasia
HE Haijuan  WANG Baolan  WANG Yunling  JIA Wenxiao 

Cite this article as: He HJ, Wang BL, Wang YL, et al. DTI quantitative evaluation of brain microstructural changes after melodic intonation therapy in the treatment of Broca aphasia[J]. Chin J Magn Reson Imaging, 2021, 12(3): 15-19. DOI:10.12015/issn.1674-8034.2021.03.004.


[Abstract] Objective To explore the characteristics of brain fiber structure changes in Broca aphasia treated with melody intonation therapy (MIT) through information of language related fiber structure provided by diffusion tensor imaging (DTI). Materials andMethods A total of 37 patients with Broca aphasia after stroke admitted to the First affiliated Hospital of Xinjiang Medical University between January 2019 and June 2020 were enrolled. Divided the patients into two groups: control group (n=19) were treated with routine speech therapy, experimental group (n=18) were treated with MIT and routine speech therapy. Patients in both groups underwent DTI before and 2 months after the therapy. The fractional anisotropy (FA) of bilateral Broca area and arcuate fasciculus were measured before and after the therapy in experimental group. FA of both Broca area and arcuate fasciculus before and after treatment were compared between the experimental group and the control group.Results Comparison of experimental group before and after therapy showed: FA of both Broca and arcuate fasciculus were statistically significant (Bilateral arcuate fasciculus and left Broca area P＜0.001, Right Broca area P=0.008). There was no significant difference in FA of bilateral Broca area and arcuate fasciculus between the experimental group and the control group before therapy (right Broca P=0.154, left Broca P=0.228, right arcuate fasciculus P=0.361, left arcuate fasciculus P=0.135). Two months after thrapy, between the experimental group and the control group, FA of right arcuate fasciculus were statistically significant (P=0.008). There was no significant difference in FA between left arcuate fasciculus and bilateral Broca (right Broca P=0.138, left Broca P=0.093, left arcuate fasciculus P=0.259).Conclusions After MIT intensive rehabilitation therapy for patients with Broca aphasia, the FA of the right arcuate fasciculus increased, suggesting that the therapeutic mechanism of MIT is related to the structural changes of the right arcuate fasciculus.
[Keywords] magnetic resonance imaging；diffusion tensor imaging；arcuate fasciculus；melody intonation therapy；broca aphasia

HE Haijuan1   WANG Baolan2   WANG Yunling2*   JIA Wenxiao2  

1 Imaging Center, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China

2 Imaging Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

Wang YL, E-mail: 1079806994@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Natural Science Found of China No. 81860407
Received  2020-08-25
Accepted  2021-01-21
DOI: 10.12015/issn.1674-8034.2021.03.004
Cite this article as: He HJ, Wang BL, Wang YL, et al. DTI quantitative evaluation of brain microstructural changes after melodic intonation therapy in the treatment of Broca aphasia[J]. Chin J Magn Reson Imaging, 2021, 12(3): 15-19. DOI:10.12015/issn.1674-8034.2021.03.004.

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