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• Clinical Article •
Comparation of amide proton transfer-weighted and T2 mapping in quantifying rectal cancer with and without chemotherapy: a preliminary study
DONG Wan  CHEN Anliang  LIU Ailian  LIU Yunsong  LIN Tao  WANG Jiazheng  SONG Qingwei 

Cite this article as: Dong W, Chen AL, Liu AL, et al. Comparation of amide proton transfer-weighted and T2 mapping in quantifying rectal cancer with and without chemotherapy: a preliminary study[J]. Chin J Magn Reson Imaging, 2021, 12(7): 24-28. DOI:10.12015/issn.1674-8034.2021.07.005.


[Abstract] Objective To explore the value of amide proton transfer-weighted (APTw) and T2 mapping quantitative parameters in the comparative study of chemotherapy and non-chemotherapy lesions of rectal cancer. Materials andMethods Data from 46 patients with rectal cancer undergoing pelvic MRI at 3.0 T in our hospital were retrospectively analyzed, including 15 cases with chemotherapy (group A) and 31 cases without chemotherapy (group B). Scanning sequences included ATPw, T2 mapping and so on. Referring to the anatomical location obtained on T2 weighted imaging (T2WI), diffusion weighted imaging (DWI) and dynamic contrast enhancement MRI (DCE-MRI) images, the axial largest lesions corresponding to APTw and T2 mapping parameter images were selected, and three ROI were placed at this level, respectively, by two radiologists. The values of APTw and T2 were measured. The data were tested with inter-class correlation coefficient (ICC) to evaluate inter-observer agreement. Independent sample t-test or Mann-Whitney U was used to test the difference of APTw and T2 values between the two groups. Logistic regression was used to calculate the predicted value of APTw-T2 mapping joint parameters. The ROC curves of the parameters that were different between the two groups were evaluated respectively. Delong test was used to compare the efficacy among APTw, T2 mapping and their combined parameters.Results The data consistency of two doctors was good (ICC＞0.75). The APTw and T2 values in group A were 1.52%±0.56% and (72.67±8.56) ms, respectively, which were both significantly lower (P＜0.05) than those in group B [APTw: 2.88% (0.77%), and T2: 86.31 (8.77) ms]. AUC of APTw and T2 values to differentiate group A and B were 0.934 and 0.923, respectively. The sensitivity, specificity and threshold value of APTw and T2 values in differentiating the two groups were 93.5%, 93.3%, 2.11% and 90.3%, 86.7%, 80.79 ms, respectively. For the predicted value of APTw-T2 mapping of the two groups, the AUC, sensitivity and specificity were 0.981, 100% and 96.8%, respectively. Delong test showed that there was no significant difference in AUC among APTw-T2 mapping, APTw and T2 mapping.Conclusions Both APTw and T2 mapping can quantitatively distinguish rectal cancer lessions with chemotherapy from no chemotherapy.
[Keywords] magnetic resonance imaging；amide proton transfer-weighted；T2 mapping；rectal cancer；chemotherapy

DONG Wan1   CHEN Anliang1   LIU Ailian1*   LIU Yunsong1   LIN Tao1   WANG Jiazheng2   SONG Qingwei1  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 Department of Clinical, Philips Healthcare, Beijing 100000, China

Liu AL, E-mail: liuailian@dmu.edu.cn

Conflicts of interest   None.

Received  2021-02-04
Accepted  2021-03-19
DOI: 10.12015/issn.1674-8034.2021.07.005
Cite this article as: Dong W, Chen AL, Liu AL, et al. Comparation of amide proton transfer-weighted and T2 mapping in quantifying rectal cancer with and without chemotherapy: a preliminary study[J]. Chin J Magn Reson Imaging, 2021, 12(7): 24-28. DOI:10.12015/issn.1674-8034.2021.07.005.

1
Siegel RL, Miller KD, Fuchs HE, et al. Cancer Statistics, 2021[J]. CA Cancer J Clin, 2021, 71(1): 7-33. DOI: 10.3322/caac.21654.
2
Hospital Authority of National Health Commission of the People's Republic of China. Chinese Society of Oncology, Chinese Medical Association. Chinese protocol of diagnosis and treatment of colorectal cancer (2020 edition)[J]. Chin J Pract Surg, 2020, 40(6): 601-625. DOI: 10.19538/j.cjps.issn1005-2208.2020.06.01.
3
Martens MH, Maas M, Heijnen LA, et al. Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer. J Natl Cancer Inst, 2016, 108(12): djw171. DOI: 10.1093/jnci/djw171.
4
Liu JL, Lin JZ, Su X, et al. Application of high resolution dynamic enhanced MR scan in TN staging and operation mode selection of rectal cancer before operation[J]. Chin J Magn Reson Imaing, 2021,12(1): 38-42. DOI: 10.12015/issn.1674-8034.2021.01.008.
5
van der Paardt MP, Zagers MB, Beets-Tan RG, et al. Patients who undergo preoperative chemoradiotherapy for locally advanced rectal cancer restaged by using diagnostic MR imaging: a systematic review and meta-analysis. Radiology2013, 269(1): 101-112. DOI: 10.1148/radiol.13122833.
6
Zhang H, Cui YY, Feng J, et al. Diagnostic and predictive efficacy of amide proton transfer mri in tumor grading, isocitrate dehydrogenase status and the expression level of Ki-67 and p53 in gliomas[J]. Chin J Med Imaging, 2020, 28(5): 327-332. DOI: 10.3969/j.issn.1005-5185.2020.05.002.
7
Wu B, Jia F, Li X, al at. Comparative study of amide proton transfer imaging and intravoxel incoherent motion imaging for predicting histologic grade of hepatocellular carcinoma[J]. Front Oncol, 2020, 10: 562049. DOI: 10.3389/fonc.2020.562049.
8
Wang F, Zhang H, Wu C, et al. Quantitative T2 mapping accelerated by GRAPPATINI for evaluation of muscles in patients with myositis[J]. Br J Radiol, 2019, 92(1102): 20190109. DOI: 10.1259/bjr.20190109.
9
Hoffman DH, Ayoola A, Nickel D, et al. T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis[J]. Abdom Radiol (NY), 2020, 45(3): 692-700. DOI: 10.1007/s00261-019-02382-9.
10
Foltz WD, Chopra S, Chung P, et al. Clinical prostate T2 quantification using magnetization-prepared spiral imaging. Magn Reson Med, 2010, 64(4): 1155-1161. DOI: 10.1002/mrm.22492.
11
Ran J, Ji S, Morelli JN, et al. T2 mapping in dermatomyositis/polymyositis and correlation with clinical parameters. Clin Radiol, 2018, 73(12): 1057.e13-1057.e18. DOI: 10.1016/j.crad.2018.07.106.
12
Mou J, Wang D, Liu XF, et al. The application value of T2-mapping sequence of cardiovascular magnetic resonance imaging to monitor myocardial inflammation in acute myocarditis[J]. Radiol Practice, 2020, 35(11): 1424-1428. DOI: 10.13609/j.cnki.1000-0313.2020.11.011.
13
Renner N, Kleyer A, Krönke G, et al. T2 mapping as a new method for quantitative assessment of cartilage damage in rheumatoid arthritis[J]. J Rheumatol, 2020, 47(6): 820-825. DOI: 10.3899/jrheum.180728.
14
Yamada I, Yoshino N, Hikishima K, et al. Colorectal carcinoma: ex vivo evaluation using 3-T high-spatial-resolution quantitative T2 mapping and its correlation with histopathologic findings[J]. Magn Reson Imaging, 2017, 38: 174-181. DOI: 10.1016/j.mri.2016.12.028.
15
Zhou J, Payen JF, Wilson DA, et al. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI[J]. Nat Med, 2003, 9(8): 1085-1090. DOI: 10.1038/nm907.
16
van Zijl PCM, Zhou J, Mori N, et al. Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids[J]. Magn Reson Med, 2003, 49(3): 440-449. DOI: 10.1002/mrm.10398.
17
Zou T, Yu H, Jiang C, et al. Differentiating the histologic grades of gliomas preoperatively using amide proton transfer-weighted (APTW) and intravoxel incoherent motion MRI[J]. NMR Biomed, 2018, 31(1): 10.1002/nbm.3850. DOI: 10.1002/nbm.3850.
18
Hou MY, Meng N, Wang J, et al. A comparative study of amide proton transfer imaging and diffusion weighted imaging for assessing cervical squamous cell carcinoma and evaluating its histological grading[J]. Radiol Practice, 2021, 36(1): 98-102. DOI: 10.13609/j.cnki.1000-0313.2021.01.019.
19
Kumari N, Thakur N, Cho HR, et al. Assessment of early therapeutic response to nitroxoline in temozolomide-resistant glioblastoma by amide proton transfer imaging: a preliminary comparative study with diffusion-weighted imaging[J]. Sci Rep, 2019, 9(1): 5585. DOI: 10.1038/s41598-019-42088-y.
20
Qamar S, King AD, Ai QY, et al. Amide proton transfer MRI detects early changes in nasopharyngeal carcinoma: providing a potential imaging marker for treatment response[J]. Eur Arch Otorhinolaryngol, 2019, 276(2): 505-512. DOI: 10.1007/s00405-018-5231-x.
21
Nishie A, Asayama Y, Ishigami K, et al. Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer[J]. J Gastroenterol Hepatol, 2019, 34(1): 140-146. DOI: 10.1111/jgh.14315.

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