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• Clinical Article •
An explorative resting-state fMRI study of central mechanism in patients with primary dysmenorrhea during menstrual phase by using the method of degree centrality
LIU Ni  ZHANG Ya'nan  WU Junchen  HAO Ying  LI Wenxun  XIA Jing  LIU Zhidan  LI Yingqiu  HUANG Yiran  HUO Jianwei 

Cite this article as: Liu N, Zhang YN, Wu JC, et al. An explorative resting-state fMRI study of central mechanism in patients with primary dysmenorrhea during menstrual phase by using the method of degree centrality[J]. Chin J Magn Reson Imaging, 2021, 12(7): 29-33. DOI:10.12015/issn.1674-8034.2021.07.006.


[Abstract] Objective To investigate the central mechanism during menstrual phase in patients with primary dysmenorrhea (PDM) by using the method of degree centrality (DC) based on resting-state functional magnetic resonance imaging (rs-fMRI). Materials andMethods Thirty-five patients (PDM group) and forty-one healthy women (HC group) were recruited for the study. The clinical data of two groups was performed, including Visual Analogue Scale for Pain and Anxiety, accompanying Symptom Score of Dysmenorrhea. Meanwhile, rs-fMRI data were collected. The difference of DC values between the two groups and the correlation between DC values in different brain regions and clinical data were analyzed by using DPABI software.Results Compared to the healthy controls, patients with PDM demonstrated significantly increased DC values in the bilateral middle frontal gyrus, left orbital superior frontal gyrus and precuneus, and decreased values in the left brainstem, superior and middle temporal gyrus (Gaussian random field corrected, voxel P＜0.001, cluster P＜0.05, two tailed). The DC value of the right middle frontal gyrus was negatively correlated with the course of disease (r=0.383, P=0.023).Conclusions Among the central mechanisms during menstrual phase in PDM patients, the prefrontal region may be involved in the compensatory brain activity in response to cognitive regulation of pain,, while the precuneus may be involved in the central pain sensitization mechanism. The cerebellum and brainstem may also be involved in pain-related processing.
[Keywords] primary dysmenorrhea；menstruation；resting-state functional magnetic resonance imaging；degree centrality；brain network

LIU Ni1   ZHANG Ya'nan1   WU Junchen1   HAO Ying2   LI Wenxun3   XIA Jing3   LIU Zhidan3   LI Yingqiu3   HUANG Yiran3*   HUO Jianwei1*  

1 Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

2 Beijing International Center for Mathematical Research, Peking University, Beijing 100871, China

3 School of Acupuncture Moxibustion & Tuina, Beijing University of Chinese Medicine, Beijing 100029, China

Huo JW, E-mail: huojianwei@bjzhongyi.com Huang YR, E-mail: caicai13@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This article is supported by the National Natural Science Foundation of China (No. 81503652).
Received  2021-02-24
Accepted  2021-04-06
DOI: 10.12015/issn.1674-8034.2021.07.006
Cite this article as: Liu N, Zhang YN, Wu JC, et al. An explorative resting-state fMRI study of central mechanism in patients with primary dysmenorrhea during menstrual phase by using the method of degree centrality[J]. Chin J Magn Reson Imaging, 2021, 12(7): 29-33. DOI:10.12015/issn.1674-8034.2021.07.006.

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