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• Clinical Article •
Effect of vestibular rehabilitation on spontaneous brain activity in patients with vestibular migraine: a resting state MRI study
QIN Xin  HU Xiaofei  CHEN Jie  WANG Qingzhen  LIU He  WANG Yao  LUO Wei  LI Guangjian  WANG Jian 

Cite this article as: Qin X, Hu XF, Chen J, et al. Effect of vestibular rehabilitation on spontaneous brain activity in patients with vestibular migraine: a resting state MRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 1-5. DOI:10.12015/issn.1674-8034.2021.09.001.


[Abstract] Objective To evaluate the effect of vestibular rehabilitation (VR) training on spontaneous neural activity, and to explore the neuropathological mechanism in vestibular migraine (VM) treatment in patients with VM by resting state functional magnetic resonance imaging (fMRI). Materials andMethods Fourteen patients with VM who were diagnosed for the first time and did not receive VR training within 6 months were included in this study. They were examined with resting state fMRI before and after VR training for one month. The clinical related indexes including Dizziness Handicap Inventory (DHI), Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) scores were collected. The changes of spontaneous neural activity in VM patients after VR training were observed, and the amplitude of low-frequency fluctuation (ALFF) of brain regions with statistical differences were extracted. The correlation analysis was performed with clinical related scores.Results After one month of VR training, the ALFF values in the right partial insula and frontal triangle of VM patients were significantly reduced, and the difference was statistically significant (GRF correction, P＜0.05), and the ALFF values in the right insula of VM patients after VR training were positively correlated with the DHI score after VR training (r=0.549, P＜0.05).Conclusions After VR training, the activity of right insular lobe and part of frontal lobe in VM patients was weakened, which may be the neuropathological mechanism of VM migraine. There was a positive correlation between the degree of symptom relief and the decrease of right insular nerve activity in VM patients.
[Keywords] vestibular migraine；vestibular rehabilitation；resting state functional magnetic resonance imaging；amplitude of low-frequency fluctuation；insular lobe

QIN Xin1, 2   HU Xiaofei1   CHEN Jie2   WANG Qingzhen2   LIU He1   WANG Yao1   LUO Wei1   LI Guangjian3*   WANG Jian1  

1 Department of Radiology, the First Affiliated Hospital of the Army Military Medical University, Chongqing 400038, China

2 Department of Radiology, Xingyi People′s Hospital of Guizhou Province, Xingyi 562400, China

3 Department of Neurology, the First Affiliated Hospital of the Army Military Medical University, Chongqing 400038

Li GJ, E-mail: 34018380@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81701664). National Key Research and Development Program of China (No. 2016YFC0107101).
Received  2021-04-23
Accepted  2021-06-11
DOI: 10.12015/issn.1674-8034.2021.09.001
Cite this article as: Qin X, Hu XF, Chen J, et al. Effect of vestibular rehabilitation on spontaneous brain activity in patients with vestibular migraine: a resting state MRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 1-5. DOI:10.12015/issn.1674-8034.2021.09.001.

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