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• Clinical Article •
Preliminary application of amide proton transfer-MRI in diagnosis of nasopharyngeal carcinomas
YANG Qian  ZOU Liyan  LIU Zhou  LI Li  XIAO Jiahui  WANG Mingyu  WANG Siyuan  LUO Dehong 

Cite this article as: Yang Q, Zou LY, Liu Z, et al. Preliminary application of amide proton transfer-MRI in diagnosis of nasopharyngeal carcinomas[J]. Chin J Magn Reson Imaging, 2021, 12(9): 6-10. DOI:10.12015/issn.1674-8034.2021.09.002.


[Abstract] Objective To explore the potential value of applying amide proton transfer weighted imaging (APT-weighted imaging) in nasopharynx. Materials andMethods From June 2020 to February 2021, 50 patients with pathologically confirmed nasopharyngeal carcinoma (NPC) who have undergone APT-weighted imaging were retrospective enrolled, and their APT-weighted imaging and clinicopathological data were collected. Two radiologists independently evaluated the performance of APT map in depicting the NPC lesion and their consistency was tested using Kendall's Tau-b was used to analyze the consistency of the results by the two radiologists. Paired t-test was used to analyze the consistency in the APT values between the left and right side of temporal muscles, parotid glands, cerebellum and turbinate and the difference in the APT values between nasopharyngeal carcinoma tissue and normal nasopharyngeal left and right temporal muscle, parotid glands, cerebellum and turbinate on the same slice. Student t-test was used to compare APT values between differentiated and undifferentiated subtypes of NPC.Results In terms of performance of lesion depiction, two radiologists agreed with a correlation coefficient of 0.844. There were no significantly difference in APT values between left and right of temporal muscles, parotid glands, cerebellum, and turbinates (P=0.475, 0.765, 0.443, and 0.544, respectively). The difference in APT values between nasopharyngeal carcinoma lesions and normal nasopharyngeal and parotid gland tissues was not statistically significant (P=0.338 vs. P=0.664 & 0.933), but the APT values of nasopharyngeal carcinoma lesions were significantly higher than the left and right temporal muscles and cerebellum tissues (P＜0.001), but lower than the turbinate tissue (P＜0.001). When it comes to subtypes of NPC, no significant difference was found in APT values between differentiated 1.97%±0.89% and undifferentiated NPC 1.95%±0.82%.Conclusions This study showed that APT imaging is satisfactory in depicting nasopharyngeal lesions, and technically feasible in the nasopharyngeal area. APT effect of different tissue types can be accurately quantified in this area, which provides practical experience in clinically applying APT imaging to the nasopharynx.
[Keywords] nasopharyngeal carcinoma；magnetic resonance imaging；amide proton transfer；head and neck tissues

YANG Qian1   ZOU Liyan1   LIU Zhou1   LI Li1   XIAO Jiahui1   WANG Mingyu1   WANG Siyuan1   LUO Dehong1, 2*  

1 Department of Radiology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China

2 Department of Radiology, National Cancer Center, National Clinical Research Center for Cancer, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Luo DH, E-mail: cjr.luodehong@vip.163.com

Conflicts of interest   None.

致谢： 感谢GE公司磁共振科研团队钱龙博士提供的技术支持。
Received  2021-04-12
Accepted  2021-06-22
DOI: 10.12015/issn.1674-8034.2021.09.002
Cite this article as: Yang Q, Zou LY, Liu Z, et al. Preliminary application of amide proton transfer-MRI in diagnosis of nasopharyngeal carcinomas[J]. Chin J Magn Reson Imaging, 2021, 12(9): 6-10. DOI:10.12015/issn.1674-8034.2021.09.002.

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