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• Clinical Article •
The study of high-resolution diffusion tensor imaging in thyroid-associated ophthalmopathy
ZHANG Xiaohui  ZHANG Zhiwei  LÜ Fajin  LIU Cun  LONG Jian  YU Bin  LI Yongmei 

Cite this article as: Zhang XH, Zhang ZW, Lü FJ, et al. The study of high-resolution diffusion tensor imaging in thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2021, 12(9): 11-14. DOI:10.12015/issn.1674-8034.2021.09.003.


[Abstract] Objective To study the application of high-resolution MR diffusion readout-segmented of long variable echo-trains diffusion tensor imaging (Resolve DTI) in the early stage of optic nerve microstructure injury in patients with thyroid associated ophthalmopathy (TAO). Materials andMethods Thirty TAO patients and 30 age and sex matched healthy controls (HC) were enrolled in this study. Conventional MRI and Resolve DTI sequences were used to scan the orbit respectively. FA, ADC, AD and RD values of bilateral optic nerves were measured. Quantitative parameters related to DTI of bilateral optic nerves were compared between patients and HC.Results FA value of bilateral optic nerves in TAO patients was significantly lower than that of HC (P=0.009, P=0.003; P＜0.05), ADC and AD value had no significant difference (P=0.364, P=0.053, P=0.955, P=0.211; P＞0.05), and RD value was higher than that of HC (P=0.010, P=0.009; P＜0.05).Conclusions Resolve DTI imaging technology is helpful to provide objective basis for the damage of the early stage of optic nerve microstructure injury in TAO patients, and to provide help for the treatment of optic neuropathy in TAO patients.
[Keywords] thyroid associated ophthalmopathy；optic nerve；readout-segmented of long variable echo-trains diffusion tensor imaging；fractional anisotropy；apparent diffusion coefficient

ZHANG Xiaohui1   ZHANG Zhiwei1   LÜ Fajin1   LIU Cun2   LONG Jian2   YU Bin1   LI Yongmei1*  

1 Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

2 Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Li YM, E-mail: lymzhang70@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS The National Key Research and Development Plan of Ministry of Science and Technology of the People's Republic of China (No. 2016YFC0107109). The Medical Scientific Youth Project of Chongqing Municipal Health and Family Planning Commission of China (No. 2018QNXM004). Chongqing Kewei Joint Medical Research Project (No. 2020MSXM119).
Received  2021-04-24
Accepted  2021-06-22
DOI: 10.12015/issn.1674-8034.2021.09.003
Cite this article as: Zhang XH, Zhang ZW, Lü FJ, et al. The study of high-resolution diffusion tensor imaging in thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2021, 12(9): 11-14. DOI:10.12015/issn.1674-8034.2021.09.003.

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