Share：
Share this content in WeChat
X
[Chinese][PDF]78763
• Clinical Article •
Study on the relationship between signal intensity parameters of liver lobes and albumin-bilirubin grades in magnetic resonance images enhanced with Gd-EOB-DTPA
LIU Guanchen  SUN Peng  TIAN Yuan  MENG Xiangge  SU Yexin  LIU Pengfei 

Cite this article as: Liu GC, Sun P, Tian Y, et al. Study on the relationship between signal intensity parameters of liver lobes and albumin-bilirubin grades in magnetic resonance images enhanced with Gd-EOB-DTPA[J]. Chin J Magn Reson Imaging, 2022, 13(1): 37-41. DOI:10.12015/issn.1674-8034.2022.01.008.


[Abstract] Objective To investigate the relationship between lobar based signal intensity parameters and Albumin - Bilirubin (ALBI) grade in patients with chronic hepatitis B-related liver cirrhosis on gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) enhanced MRI.Materials and Methods: Gd-EOB-DTPA enhanced MRI images of 62 patients with normal liver (n=15), ALBI grade 1 (n=23), ALBI grade 2 (n=18), and ALBI grade 3 (n=6) with chronic hepatitis B associated cirrhosis were analyzed. Liver parenchyma relative enhancement (LRE) and liver-to-muscle ratio (LMR) of right lobe, left medial lobe, left lateral lobe and caudate lobe were calculated, and compared between normal group and different ALBI grading groups. The relationship between LRE, LMR and ALBI grading of liver lobes in patients with chronic hepatitis B-related cirrhosis was quantitatively analyzed, and the accuracy of ALBI grade 1 and ALBI grade 2-3 were evaluated by ROC curve.Results The LRE and LMR values of each liver lobe were significantly different between the normal group and different ALBI grading groups (P＜0.05). The pairings of each group showed that there was no significant difference in LRE value of each liver lobe between ALBI 2 and ALBI 3 groups (P＞0.05), and there was a significant difference in LMR value of each liver lobe between any two groups (P＜0.001). The LRE and LMR of each lobe of liver in patients with chronic hepatitis B-related liver cirrhosis were negatively correlated with ALBI grade (P＜0.001). LRE in the right lobe of the liver had the highest accuracy in distinguishing ALBI grade 1 from ALBI grade 2-3, and the area under the receiver operating characteristic curve is 0.913.Conclusions There is a correlation between LRE and LMR based on liver lobe and ALBI grade of liver function in patients with chronic hepatitis B related cirrhosis in Gd-EOB-DTPA enhanced MRI. LRE and LMR are expected to be imaging methods to evaluate liver lobe function.
[Keywords] liver cirrhosis；magnetic resonance imaging；gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid；quantitative evaluation；liver function

LIU Guanchen   SUN Peng   TIAN Yuan   MENG Xiangge   SU Yexin   LIU Pengfei  

Department of MRI, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Liu PF, E-mail: Pfeiliu@hotmail.com

Conflicts of interest   None.

Received  2021-07-30
Accepted  2021-11-25
DOI: 10.12015/issn.1674-8034.2022.01.008
Cite this article as: Liu GC, Sun P, Tian Y, et al. Study on the relationship between signal intensity parameters of liver lobes and albumin-bilirubin grades in magnetic resonance images enhanced with Gd-EOB-DTPA[J]. Chin J Magn Reson Imaging, 2022, 13(1): 37-41. DOI:10.12015/issn.1674-8034.2022.01.008.

[1]
Ren H, Liu Y, Lu J, et al. Evaluating the clinical value of MRI multi-model diffusion-weighted imaging on liver fibrosis in chronic hepatitis B patients[J]. Abdom Radiol (NY), 2021, 46(4): 1552-1561. DOI: 10.1007/s00261-020-02806-x.
[2]
Yang M, Zhang Y, Zhao W, et al. Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-D TPA-enhanced MRI[J]. BMC Med imaging, 2020, 20(1): 119. DOI: 10.1186/s12880-020-00519-7.
[3]
Johnson PJ, Berhane S, Kagebayashi C, et al. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade[J]. J Clin Oncol, 2015, 33(6): 550-558. DOI: 10.1200/JCO.2014.57.9151.
[4]
Ippolito D, Pecorelli A, Famularo S, et al. Assessing liver function: diagnostic efficacy of parenchymal enhancement and liver volume ratio of Gd-EOB-DTPA-enhanced MRI study during interstitial and hepatobiliary phase[J]. Abdom Radiol (NY), 2019, 44(4): 1340-1349. DOI: 10.1007/s00261-018-1812-9.
[5]
Liu MT, Zhang XQ, Lu J, et al. Evaluation of liver function using the hepatocyte enhancement fraction based on gadoxetic acid-enhanced MRI in patients with chronic hepatitis B[J]. Abdom Radiol (NY), 2020, 45(10): 3129-3135. DOI: 10.1007/s00261-020-02478-7.
[6]
Ding Y, Rao S, Yang L, et al. Comparison of the effect of region-of-interest methods using gadoxetic acid-enhanced MR imaging with diffusion-weighted imaging on staging hepatic fibrosis[J]. Radiol Med, 2016, 121(11): 821-827. DOI: 10.1007/s11547-016-0669-7.
[7]
Haimerl M, Verloh N, Zeman F, et al. Gd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry[J]. Sci Rep, 2017, 7: 43347. DOI: 10.1038/srep43347.
[8]
Tamada T, Ito K, Higaki A, et al. Gd-EOB-DTPA-enhanced MR imaging: evaluation of hepatic enhancement effects in normal and cirrhotic livers[J]. Eur J Radiol, 2011, 80(3): e311-e316. DOI: 10.1016/j.ejrad.2011.01.020.
[9]
Motosugi U, Ichikawa T, Sou H, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement?[J]. J Magn Reson Imaging, 2009, 30(5): 1042–1046. DOI: 10.1002/jmri.21956.
[10]
Nishie A, Ushijima Y, Tajima T, et al. Quantitative analysis of liver function using superparamagnetic iron oxide- and Gd-EOB-DTPA-enhanced MRI: comparison with Technetium-99m galactosyl serum albumin scintigraphy[J]. Eur J Radiol, 2012, 81(6): 1100-1104. DOI: 10.1016/j.ejrad.2011.02.053.
[11]
Poetter-Lang S, Bastati N, Messner A, et al. Quantification of liver function using gadoxetic acid-enhanced MRI[J]. Abdom Radiol (NY), 2020, 45(11): 3532-3544. DOI: 10.1007/s00261-020-02779-x.
[12]
Qiu T, Fu R, Ling W, et al. Comparison between preoperative two-dimensional shear wave elastography and indocyanine green clearance test for prediction of post-hepatectomy liver failure[J]. Quant Imaging Med Surg, 2021, 11(5): 1692-1700. DOI: 10.21037/qims-20-640.
[13]
Xu XY, Ding HG, Li WG, et al. Guidelines for liver cirrhosis[J]. J Clin Hepatol, 2019, 35(11): 2408-2405.
[14]
Harada TL, Saito K, Araki Y, et al. Prediction of high-stage liver fibrosis using ADC value on diffusion-weighted imaging and quantitative enhancement ratio at the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI at 1.5 T[J]. Acta Radiol, 2018, 59(5): 509-516. DOI: 10.1177/0284185117725778.
[15]
Ippolito D, Famularo S, Giani A, et al. Estimating liver function in a large cirrhotic cohort: Signal intensity of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI[J]. Dig Liver Dis, 2019, 51(10): 1438-1445. DOI: 10.1016/j.dld.2019.04.009.
[16]
Pan S, Wang XQ, Guo QY. Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging[J]. World J Gastroenterol, 2018, 24(18): 2024-2035. DOI: 10.3748/wjg.v24.i18.2024.
[17]
Zhou ZP, Long LL, Qiu WJ, et al. Comparison of 10- and 20-min hepatobiliary phase images on Gd-EOB-DTPA-enhanced MRI T1 mapping for liver function assessment in clinic[J]. Abdom Radiol (NY), 2017, 42(9): 2272-2278. DOI: 10.1007/s00261-017-1143-2.
[18]
Zhang W, Wang X, Miao Y, et al. Liver function correlates with liver-to-portal vein contrast ratio during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MR at 3 Tesla[J]. Abdom Radiol (NY), 2018, 43(9): 2262-2269. DOI: 10.1007/s00261-018-1462-y.
[19]
Haimerl M, Utpatel K, Verloh N, et al. Gd-EOB-DTPA-enhanced MR relaxometry for the detection and staging of liver fibrosis[J]. Sci Rep, 2017, 7(7): 41429. DOI: 10.1038/srep41429.
[20]
Verloh N, Utpatel K, Haimerl M, et al. Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation[J]. Sci Rep, 2015, 5: 15408. DOI: 10.1038/srep15408.
[21]
Garcia-Martinez R, Caraceni P, Bernardi M, et al. Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complications[J]. Hepatology, 2013, 58(5): 1836-1846. DOI: 10.1002/hep.26338.
[22]
Inaba K, Barmparas G, Resnick S, et al. The Model for End-Stage Liver Disease score: an independent prognostic factor of mortality in injured cirrhotic patients[J]. Arch Surg, 2011, 146(9): 1074-1078. DOI: 10.1001/archsurg.2011.109.
[23]
Agrawal S, Dhiman RK, Limdi JK. Evaluation of abnormal liver function tests[J]. Postgrad Med J, 2016, 92(1086): 223-234. DOI: 10.1136/postgradmedj-2015-133715.
[24]
Wang J, Zhang Z, Yan X, et al. Albumin-Bilirubin (ALBI) as an accurate and simple prognostic score for chronic hepatitis B-related liver cirrhosis[J]. Dig Liver Dis, 2019, 51(8): 1172-1178. DOI: 10.1016/j.dld.2019.01.011.
[25]
Takatsu Y, Kobayashi S, Miyati T, et al. Hepatobiliary phase images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI as an imaging surrogate for the albumin-bilirubin grading system[J]. Eur J Radiol, 2016, 85(12): 2206-2210. DOI: 10.1016/j.ejrad.2016.10.010.
[26]
Chen XL, Chen TW, Zhang XM, et al. Quantitative assessment of the presence and severity of cirrhosis in patients with hepatitis B using right liver lobe volume and spleen size measured at magnetic resonance imaging[J]. PLoS One, 2014, 9(3): e89973. DOI: 10.1371/journal.pone.0089973.
[27]
Zhou ZP, Long LL, Qiu WJ, et al. Evaluating segmental liver function using T1 mapping on Gd-EOB-DTPA-enhanced MRI with a 3.0 Tesla[J]. BMC Med Imaging, 2017, 17(1): 20. DOI: 10.1186/s12880-017-0192-x.
[28]
Sheng RF, Wang, HQ, Yang L, et al. Assessment of liver fibrosis using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance[J]. Dig Liver Dis, 2017, 49(7): 789-795. DOI: 10.1016/j.dld.2017.02.006.

PREV Preliminary study of CMR tissue feature tracking technology on left ventricular function in patients with hypertrophic cardiomyopathy with ejection fraction preservation
NEXT Application study of MRI T2WI texture baseline predicting the efficacy of advanced rectal cancer transformation therapy for primary tumors
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn