Share：
Share this content in WeChat
X
[Chinese][PDF]45827
• Original Article •
A clinical study of amygdala volume changes in medial temporal lobe epilepsy patients
GU Xin  XU Fei  ZHANG Liling  WANG Yunling  DING Shuang 

Cite this article as: Gu X, Xu F, Zhang LL, et al. A clinical study of amygdala volume changes in medial temporal lobe epilepsy patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 36-39. DOI:10.12015/issn.1674-8034.2022.06.007.


[Abstract] Objective The changes of hippocampus and amygdala volume in patients with medial temporal lobe epilepsy were studied by using T1 three dimensional magnetization prepared rapid acquisition gradient echo (3D-T1 MPRAGE) sequence and FreeSufer software to measure the volume of hippocampus and amygdala.Materials and Methods A total of 102 patients with medial temporal lobe epilepsy (case group) and 15 healthy volunteers (control group) were collected to measure the volume of bilateral hippocampus and amygdala respectively, and the abnormality was judged by taking the mean value of the control group plus or minus 2 times the standard deviation as the normal limit. According to whether the hippocampal volume is normal or not, the patients with amygdala enlargement (AE) in the hippocampal sclerosis (HS) group and the normal hippocampal group were divided into L group and R group according to the epilepsy side. Paired t-test was used to compare bilateral amygdala volumes. One-way ANOVA was used to compare the ipsilateral amygdala of the normal hippocampus-L group, the normal hippocampal-R group and the normal control group; the ipsilateral amygdala of the HS-L group, the HS-R group and the normal control group was compared.Results The study found that there was a statistically significant difference in the volume of bilateral amygdala between normal hippocampal-L group and normal hippocampal-R group (P＜0.05). There was a statistically significant difference in the volume of bilateral amygdala between HS-L group and HS-R group (P＜0.05). The volume of the right amygdala in the HS-L group was larger than that of the HS-R group and the same side of the control group (P＜0.05). The volume of the left amygdala in the HS-R group was greater than that in the HS-L group and the same side of the control group (P＜0.05). The volume of the left amygdala in the normal hippocampus-L group was larger than that in the normal hippocampus-R group and the ipsilateral side of the control group (P＜0.05). The volume of the right amygdala in the normal hippocampus-R group was larger than that in the normal hippocampus-L group and control group on the same side (P＜0.05).Conclusions 3D-T1 MPRAGE can accurately measure the volume of the amygdala. Meanwhile, patients with normal hippocampus in mesial temporal lobe epilepsy have amygdala enlargement on the same side of the epileptogenic foci, and HS patients have amygdala enlargement on the opposite side of the epileptic foci, indicating that the amygdala may be involved in the occurrence and development of mesial temporal lobe epilepsy.
[Keywords] medial temporal lobe epilepsy；hippocampus；amygdala volume；magnetic resonance imaging；T1 three dimensional magnetization prepared rapid acquisition gradient echo sequence

GU Xin   XU Fei   ZHANG Liling   WANG Yunling   DING Shuang*  

Department of MRI, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China

Ding S, E-mail: dingshuangxxx@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Xinjiang Uygur Autonomous Region Science and Technology Supporting Xinjiang Project Plan (Instructive) Project (No. 2020E0275).
Received  2021-11-17
Accepted  2022-05-31
DOI: 10.12015/issn.1674-8034.2022.06.007
Cite this article as: Gu X, Xu F, Zhang LL, et al. A clinical study of amygdala volume changes in medial temporal lobe epilepsy patients[J]. Chin J Magn Reson Imaging, 2022, 13(6): 36-39. DOI:10.12015/issn.1674-8034.2022.06.007.

[1]
Marissal T. An inventory of basic research in temporal lobe epilepsy[J]. Rev Neurol, 2021, 177(9): 1069-1081. DOI: 10.1016/j.neurol.2021.02.390.
[2]
Pei CM, Gao Y, Qiao PF, et al. The study progress of multi-mode MRI in the idiopathic epilepsy[J]. Chin J Magn Reson Imaging, 2016, 7(6): 464-468. DOI: 10.12015/issn.1674-8034.2016.06.013.
[3]
Kohlhase K, Zöllner J P, Tandon N, et al. Comparison of minimally invasive and traditional surgical approaches for refractory mesial temporal lobe epilepsy: A systematic review and meta-analysis of outcomes[J]. Epilepsia, 2021, 62(4): 831-845. DOI: 10.1111/epi.16846.
[4]
Li W, Jiang Y, Qin Y, et al. Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery[J/OL]. NeuroImage: Clinical, 2021, 31 [2021-11-17]. https://www.sciencedirect.com/science/article/pii/S2213158221001583. DOI: 10.1016/j.nicl.2021.102714.
[5]
Tatekawa H, Uetani H, Hagiwara A, et al. Association of hypometabolic extension of 18F-FDG PET with diffusion tensor imaging indices in mesial temporal lobe epilepsy with hippocampal sclerosis[J]. Seizure, 2021, 88: 130-137. DOI: 10.1016/j.seizure.2021.04.007.
[6]
Beh SMJ, Cook MJ, D'Souza WJ. Isolated amygdala enlargement in temporal lobe epilepsy: a systematic review[J]. Epilepsy & Behav, 2016, 60: 33-41. DOI: 10.1016/j.yebeh.2016.04.015.
[7]
Reyes A, Thesen T, Kuzniecky R, et al. Amygdala enlargement: Temporal lobe epilepsy subtype or nonspecific finding?[J]. Epilepsy Res, 2017, 132: 34-40. DOI: 10.1016/j.eplepsyres.2017.02.019.
[8]
Jo H, Kim J, Kim D, et al. Lateralizing Characteristics of Morphometric Changes to Hippocampus and Amygdala in Unilateral Temporal Lobe Epilepsy with Hippocampal Sclerosis[J]. Medicina, 2022, 58(4): 480. DOI: 10.3390/medicina58040480.
[9]
Fuerst D, Shah J, Shah A, et al. Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study[J]. Ann Neurol, 2003, 53(3): 413-416. DOI: 10.1002/ana.10509.
[10]
Capizzano AA, Kawasaki H, Sainju RK, et al. Amygdala enlargement in mesial temporal lobe epilepsy: an alternative imaging presentation of limbic epilepsy[J]. Neuroradiology, 2019, 61(2): 119-127. DOI: 10.1007/s00234-018-2109-y.
[11]
Perera T, Gaxiola-Valdez I, Singh S. Calgary Comprehensive Epilepsy Program collaborators. Localizing the seizure onset zone by comparing patient postictal hypoperfusion to healthy controls[J]. J Neurosci Res, 2020, 98(8): 1517-1531. DOI: 10.1002/jnr.24646.
[12]
Zhu S, Xu ZS, Xia Q, et al. Clinico-pathological features of temporal lobe epilepsy with enlarged amygdala[J]. Journal of Peking University (Health Sciences), 2019, 51(5): 824-828. DOI: 10.19723/j.issn.1671-167X.2019.05.006.
[13]
Fan Z, Sun B, Lang L, et al. Diagnosis and surgical treatment of non-lesional temporal lobe epilepsy with unilateral amygdala enlargement[J]. Neurol Sci, 2021, 42(6): 2353-2361. DOI: 10.1007/s10072-020-04794-8.
[14]
Suzuki H, Sugano H, Nakajima M, et al. The epileptogenic zone in pharmaco‐resistant temporal lobe epilepsy with amygdala enlargement[J]. Epileptic Disord, 2019, 21(3): 252-264. DOI: 10.1684/epd.2019.1075.
[15]
Sone D, Ota M, Maikusa N, et al. White matter abnormalities in patients with temporal lobe epilepsy and amygdala enlargement: comparison with hippocampal sclerosis and healthy subjects[J]. Epilepsy Research, 2016, 127: 221-228. DOI: 10.1016/j.eplepsyres.2016.09.011.
[16]
Coan AC, Morita ME, Campos BM, et al. Amygdala enlargement occurs in patients with mesial temporal lobe epilepsy and hippocampal sclerosis with early epilepsy onset[J]. Epilepsy & Behav, 2013, 29(2): 390-394. DOI: 10.1016/j.yebeh.2013.08.022.
[17]
Tilelli CQ, Flôres LR, Cota VR, et al. Amygdaloid complex anatomopathological findings in animal models of status epilepticus[J/OL]. Epilepsy & Behav, 2021, 121 [2021-11-17]. https://www.epilepsybehavior.com/article/S1525-5050(19)30282-3/fulltext. DOI: 10.1016/j.yebeh.2019.106831.
[18]
Na HK, Lee HJ, Hong SJ, et al. Volume change in amygdala enlargement as a prognostic factor in patients with temporal lobe epilepsy: A longitudinal study[J]. Epilepsia, 2020, 61(1): 70-80. DOI: 10.1111//epi.16400.
[19]
Guo ZH, Zhao BT, Hu WH, et al. Effective connectivity among the hippocampus, amygdala, and temporal neocortex in epilepsy patients: A cortico-cortical evoked potential study[J/OL]. Epilepsy & Behav, 2021, 115 [2021-11-17]. https://www.epilepsybehavior.com/article/S1525-5050(20)30841-6/fulltext. DOI: 10.1016/j.yebeh.2020.107661.
[20]
Kullmann DM. What's wrong with the amygdala in temporal lobe epilepsy?[J]. Brain, 2011, 134(10): 2800-2801. DOI: 10.1093/brain/awr246.
[21]
Mégevand P, Groppe DM, Bickel S, et al. The hippocampus and amygdala are integrators of neocortical influence: a corticocortical evoked potential study[J]. Brain Connectivity, 2017, 7(10): 648-660. DOI: 10.1089/brain.2017.0527.
[22]
Mo J, Zhao B, Adler S, et al. Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis[J]. Quant Imag Med Surg, 2021, 11(5): 1782-1795. DOI: 10.21037/qims-20-624.
[23]
Lee DA, Lee HJ, Kim HC, et al. Temporal lobe epilepsy with or without hippocampal sclerosis: Structural and functional connectivity using advanced MRI techniques[J]. J Neuroimaging, 2021, 31(5): 973-980. DOI: 10.1111/jon.12898.
[24]
Bruxel EM, Bruno DCF, do Canto AM, et al. Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease[J]. Seizure, 2021, 90: 34-50. DOI: 10.1016/j.seizure.2021.03.002.

PREV Structural damage of the corpus callosum connecting interhemispheric homologous areas correlated with motor dysfunction after subcortical stroke
NEXT Investigate the whole level alteration of dynamic functional connectivity of attention network in patients with major depressive disorder based on magnetic resonance imaging
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn