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• Original Article •
Investigate the whole level alteration of dynamic functional connectivity of attention network in patients with major depressive disorder based on magnetic resonance imaging
LIU Sha  ZHANG Xun  HUANG Guimao  DU Biyin  CHEN Junhao  CHENG Xiaofang  ZOU Wenjin 

Cite this article as: Liu S, Zhang X, Huang GM, et al. Investigate the whole level alteration of dynamic functional connectivity of attention network in patients with major depressive disorder based on magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2022, 13(6): 40-44. DOI:10.12015/issn.1674-8034.2022.06.008.


[Abstract] Objective To explore the abnormalities of dynamic connectivity of attention network in patients with major depressive disorder (MDD) by using resting state-functional magnetic resonance imaging (rs-fMRI).Materials and Methods Totally, 73 MDD subjects and 71 healthy controls (HC) were included in this study. The rs-fMRI data were acquired for each subject, and the functional network of attention was established based on previous meta-analysis. Then, the attention network was temporally segmented according to a series of sliding windows, and the temporal variability of attention network connectivity was calculated and then compared between the MDD and HC groups.Results Compared with the HC group, significantly increased temporal variability of attention network across all the nodes of the whole network (P=0.019) was observed in the MDD group, while no significant difference of temporal variability was observed in any individual node between the two groups. No significant correlation between the mean temporal variability of attention network and the scores of the depression and anxiety was found.Conclusions The results may indicate that the abnormally increased dynamic connectivity of attention network in patients with MDD are at the whole network level, instead of a localized change driven by regional abnormalities.
[Keywords] major depressive disorder；attention network；functional magnetic resonance imaging；dynamic connectivity；temporal variability

LIU Sha1   ZHANG Xun2   HUANG Guimao1   DU Biyin1   CHEN Junhao1   CHENG Xiaofang1   ZOU Wenjin1*  

1 Department of Radiology, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China

2 Department of Neurosurgery, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China

Zou WJ, E-mail: 46016157@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS 2017 Guangdong province Science and Technology Development Special Fund (Public Welfare Research and Capacity Building) Project (No. 2017A020215008).
Received  2021-12-17
Accepted  2022-05-12
DOI: 10.12015/issn.1674-8034.2022.06.008
Cite this article as: Liu S, Zhang X, Huang GM, et al. Investigate the whole level alteration of dynamic functional connectivity of attention network in patients with major depressive disorder based on magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2022, 13(6): 40-44. DOI:10.12015/issn.1674-8034.2022.06.008.

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