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• Original Article •
Study on time variability of brain activity in patients with irritable bowel syndrome with diarrhea based on dynamic amplitude of low-frequency fluctuation
WEN Xin  CHEN Jie  LIAO Chenxi  ZHENG Qianhua  LI Ying 

Cite this article as: Wen X, Chen J, Liao CX, et al. Study on time variability of brain activity in patients with irritable bowel syndrome with diarrhea based on dynamic amplitude of low-frequency fluctuation[J]. Chin J Magn Reson Imaging, 2022, 13(6): 61-65. DOI:10.12015/issn.1674-8034.2022.06.012.


[Abstract] Objective To investigate the changes in local brain function activity in the resting state of irritable bowel syndrome with diarrhea (IBS-D) patients.Materials and Methods Twenty-four patients with diarrhea-predominant IBS-D and 20 healthy controls underwent resting-state functional magnetic resonance imaging, the dynamic amplitude of low-frequency fluctuation (dALFF) value was calculated by using the amplitude of low-frequency fluctuation method combined with sliding window approach. Finally, the correlation analysis was performed to detect the relationship between the changes in dALFF value and some clinical data in IBS-D patients.Results The group comparison results in dALFF variability showed that patients with IBS-D exhibited increased dALFF variability in the left cerebellum(t=3.95) and right putamen (t=3.13, corrected by Alphasim, P＜0.01 after correction). The abnormal dALFF variability of the putamen was positively correlated with the abdominal pain in patients with IBS-D (r=0.398,P=0.054).Conclusions The findings indicated that the patients with IBS-D exhibited abnormal temporal variability of spontaneous neural activity in the cerebellum and putamen. Moreover, the right putamen might be related to the occurrence and development of abdominal pain in IBS-D patients.
[Keywords] irritable bowel syndrome with diarrhea；resting-state functional magnetic resonance imaging；amplitude of low-frequency fluctuations；dynamic variability；putamen

WEN Xin1   CHEN Jie1   LIAO Chenxi1   ZHENG Qianhua1   LI Ying2*  

1 School of Acupuncture-Moxibustion & Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

2 Graduate School of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

Li Y, E-mail: liying@cdutcm.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Key Research and Development Program of China (No. 2019YFC1712103); Youth Program of National Natural Science Foundation of China (No. 81804207).
Received  2022-02-22
Accepted  2022-05-20
DOI: 10.12015/issn.1674-8034.2022.06.012
Cite this article as: Wen X, Chen J, Liao CX, et al. Study on time variability of brain activity in patients with irritable bowel syndrome with diarrhea based on dynamic amplitude of low-frequency fluctuation[J]. Chin J Magn Reson Imaging, 2022, 13(6): 61-65. DOI:10.12015/issn.1674-8034.2022.06.012.

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