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• Original Article •
fMRI research on regional homogeneity and functional connectivity changes of brain regions in patients with end-stage renal disease
BAI Di  MA Chi  WANG Chengjian  ZHOU Tong  WANG Jiachen  BI Yuzhen  REN Yande 

Cite this article as: Bai D, Ma C, Wang CJ, et al. fMRI research on regional homogeneity and functional connectivity changes of brain regions in patients with end-stage renal disease[J]. Chin J Magn Reson Imaging, 2022, 13(6): 66-70. DOI:10.12015/issn.1674-8034.2022.06.013.


[Abstract] Objective To investigate the alterations of neuronal functional activity in patients with end-stage renal disease (ESRD) by using regional homogeneity (ReHo) and functional connectivity (FC) algorithm based on resting-state functional magnetic resonance imaging (rs-fMRI), and to analyze the association between spontaneous brain activity changes and blood biochemical index.Materials and Methods Thirty-six patients with ESRD and 32 healthy controls were scanned with rs-fMRI to calculate the ReHo value of the whole brain. Brain areas with altered ReHo values were selected as regions of interest for FC analysis. Two independent sample t tests was used for comparison between groups, and Pearson's correlation analysis was used between altered ReHo values and blood biochemical index.Results Compared with the healthy controls, ESRD patients showed the ReHo values in left temporal pole, right orbital inferior frontal gyrus and bilateral rectus gyrus were significantly increased (P＜0.001, AlphaSim corrected), meanwhile, the ReHo values in bilateral calcarine sulcus, left inferior frontal gyrus, right superior temporal gyrus and supramarginal gyrus were significantly decreased (P＜0.001, AlphaSim corrected). ESRD patients showed decreased FC between right calcarine sulcus and left inferior frontal gyrus and right supramarginal gyrus (P＜0.05, NBS corrected). We also found decreased FC between right supramarginal gyrus and right superior temporal gyrus (P＜0.01, NBS corrected). Correlation analyses showed that ReHo values in right calcarine sulcus were positively correlated with haemoglobin levels (r=0.347, P=0.048) and haematocrit (r=0.357, P=0.041).Conclusion ESRD patients had dyssynchrony of local functional activities in several brain regions, mainly involving the default mode network, which may contribute to further understanding of the neuropathological mechanism of brain injury in ESRD patients.
[Keywords] end-stage renal disease；resting-state functional magnetic resonance imaging；brain injury；regional homogeneity；functional connectivity

BAI Di1   MA Chi2   WANG Chengjian1   ZHOU Tong1   WANG Jiachen1   BI Yuzhen1   REN Yande1*  

1 Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China

2 Department of Radiology, Qilu Hospital of Shandong University, Qingdao 266000, China

Ren YD, E-mail: 8198458ryd@qdu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS Qingdao Medical and Health Scientific Research Project (No. 2021-WJZD192).
Received  2022-03-02
Accepted  2022-05-31
DOI: 10.12015/issn.1674-8034.2022.06.013
Cite this article as: Bai D, Ma C, Wang CJ, et al. fMRI research on regional homogeneity and functional connectivity changes of brain regions in patients with end-stage renal disease[J]. Chin J Magn Reson Imaging, 2022, 13(6): 66-70. DOI:10.12015/issn.1674-8034.2022.06.013.

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