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• Original Article •
Dynamic changes of percent amplitude of fluctuation in sleep deprivation based on resting-state fMRI
LI Leilei  WANG Xiaolei  LU Huizhen  SUN Zeheng  ZHAO Mengmeng  WANG Hong  ZHENG Jianmin  ZHU Yuanqiang 

Cite this article as: LI L L, WANG X L, LU H Z, et al. Dynamic changes of percent amplitude of fluctuation in sleep deprivation based on resting-state fMRI[J]. Chin J Magn Reson Imaging, 2023, 14(2): 92-96, 131. DOI:10.12015/issn.1674-8034.2023.02.016.


[Abstract] Objective To investigate the dynamic changes of brain spontaneous functional activity during sleep deprivation (SD) based on the percent amplitude of fluctuation (perAF).Materials and Methods A total of 36 healthy volunteers were recruited and their resting-state functional magnetic resonance imaging (fMRI) images were collected at 22:00 pm, 24:00 pm, 02:00 am, 04:00 am, and 06:00 am, respectively. Meanwhile, the Stanford Sleepiness Scale (SSS) was used to collect individual sleepiness data. One-way repeated measures ANOVA was used to compare the brain regions with different perAF dynamic changes over time (P＜0.05, FDR correction). Pearson correlation analysis was used to explore the correlation between dynamic changes of perAF value and SSS score in different brain regions.Results Significant time effects for perAF were found mainly in the bilateral thalamus, right precentral gyrus, right parietal lobule, left medial prefrontal lobe and right superior temporal gyrus (FDR correction, P＜0. 05, cluster size≥20 voxels). This means that perAF values in the above brain regions are significantly different at least two of the five time points. It was found that the right superior temporal gyrus (r=0.36, P=0.03; r=0.37, P=0.02) and left medial prefrontal lobe (r=0.33, P=0.05; r=0.41, P=0.01) at 22:00 pm and 06:00 am was positively correlated with SSS scores.Conclusions The abnormal activity of the default mode network, the frontoparietal attention network and the thalamus may be the important neural mechanism of increased sleepiness and decreased attention in individuals during sleep deprivation.
[Keywords] sleep deprivation；resting-state functional magnetic resonance imaging；percent amplitude of fluctuation；Stanford Sleepiness Scale；dynamic change

LI Leilei1   WANG Xiaolei1   LU Huizhen1   SUN Zeheng2   ZHAO Mengmeng2   WANG Hong1   ZHENG Jianmin1   ZHU Yuanqiang1*  

1 Department of Radiology, the First Affiliated Hospital of the Air Force Military Medical University, Xi'an 710032, China

2 Department of Medical Imaging, Yanliang District People's Hospital, Xi'an 710089, China

*Correspondence to: Zhu YQ, E-mail: zhu_yq_fmmu@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Basic Research Program of Natural Science of Shaanxi Province (No. 2022JM-575).
Received  2022-09-19
Accepted  2023-02-03
DOI: 10.12015/issn.1674-8034.2023.02.016
Cite this article as: LI L L, WANG X L, LU H Z, et al. Dynamic changes of percent amplitude of fluctuation in sleep deprivation based on resting-state fMRI[J]. Chin J Magn Reson Imaging, 2023, 14(2): 92-96, 131. DOI:10.12015/issn.1674-8034.2023.02.016.

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