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• Original Article •
Structural damage of the corpus callosum connecting interhemispheric homologous areas correlated with motor dysfunction after subcortical stroke
GUO Miao  XU Guojun  YU Qiurong  WANG Hewei  YIN Dazhi  SUN Limin  NING Ruipeng  LIU Fan  FAN Mingxia 

Cite this article as: Guo M, Xu GJ, Yu QR, et al. Structural damage of the corpus callosum connecting interhemispheric homologous areas correlated with motor dysfunction after subcortical stroke[J]. Chin J Magn Reson Imaging, 2022, 13(6): 28-35. DOI:10.12015/issn.1674-8034.2022.06.006.


[Abstract] Objective To investigate the relationship between the transcallosal tracts abnormality of interhemispheric homotopic regions and motor impairment in unilateral subcortical stroke.Materials and Methods Diffusion tensor imaging data of 34 patients with unilateral subcortical stroke and 43 healthy subjects were collected. Using the high-resolution transcallosal tract template (TCATT), the fractional anisotropy (FA) of 32 transcallosal tracts connecting the interhemispheric homologous brain areas (including sensory motor area, prefrontal lobe, parietal lobe, temporal lobe and occipital lobe) in the stroke group and healthy control group were calculated and compared; furthermore, correlation analysis was conducted with the FA ratio (rFA) of corticospinal tract (CST) and the Fugl-Meyer assessment of upper extremity (FM-UE), respectively.Results Compared with the healthy controls, FA values of all the 32 transcallosal tracts in the midsagittal plane decreased in the stroke group, of which 29 showed significant differences (except three transcallosal tracts connecting homotopic regions of gyrus rectus, medial orbital and paracentral lobule). FA values of the 29 transcallosal tracts in the midsagittal plane were positively correlated with rFA (CST) and FM-UE in the stroke group. There was also a significant positive correlation between rFA (CST) and FM-UE (r=0.596, P=0.0004).Conclusions This study confirms that the damage of corpus callosum microstructure in subcortical stroke is closely related to the damage of ipsilesional CST. The secondary structural injury of the corpus callosum also have an important effect on the motor impairment following subcortical stroke.
[Keywords] stroke；diffusion tensor imaging；transcallosal tracts；interhemispheric homologous areas；corticospinal tract；motor dysfunction

GUO Miao1   XU Guojun1   YU Qiurong1   WANG Hewei2   YIN Dazhi3   SUN Limin2   NING Ruipeng1   LIU Fan1   FAN Mingxia1*  

1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

2 Huashan Hospital, Fudan University, Shanghai 200040, China

3 Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China

Fan MX, E-mail: mxfan@phy.ecnu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81974356); Young National Natural Science Foundation of China (No. 82102665); National Key R&D Program of China (No. 2020YFC2004200).
Received  2022-03-23
Accepted  2022-05-20
DOI: 10.12015/issn.1674-8034.2022.06.006
Cite this article as: Guo M, Xu GJ, Yu QR, et al. Structural damage of the corpus callosum connecting interhemispheric homologous areas correlated with motor dysfunction after subcortical stroke[J]. Chin J Magn Reson Imaging, 2022, 13(6): 28-35. DOI:10.12015/issn.1674-8034.2022.06.006.

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